{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:20:56Z","timestamp":1791091256365,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,6,18]],"date-time":"2003-06-18T00:00:00Z","timestamp":1055894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We carried out a prospective evaluation of a new vasodilator\u2010stimulated phosphoprotein (VASP) phosphorylation assay in order to detect patients with high\u2010risk coronary subacute stent thrombosis (SAT) despite thienopyridine regimen. Twenty healthy donors (group 1) without any medication were compared to 16 stented patients (group 2) treated by ticlopidin or clopidogrel initiated 2 days before stenting and aspirin (250 mg\/day). No difference in platelet reactivity was noted between group 1 and group 2 treated only with aspirin (72.00% \u00b1 4.17% vs. 69.73% \u00b1 5.62%, respectively; <jats:italic>P<\/jats:italic> = NS). Significant differences were found between patients of group 2 treated with aspirin alone (69.73% \u00b1 5.62%), after 2.0 days (60.14% \u00b1 9.60%; <jats:italic>P<\/jats:italic> &lt; 0.05), and after 4.8 \u00b1 1.3 days (48.37% \u00b1 11.19%; <jats:italic>P<\/jats:italic> &lt; 0.05) with thienopyridine\u2010aspirin. Among 1,684 consecutive stented patients, 16 patients who presented an SAT (group 3) were compared with 30 other stented patients free of SAT (group 4). We found a significant difference between group 3 (63.28% \u00b1 9.56%) and group 4 (39.80% \u00b1 10.9%; <jats:italic>P<\/jats:italic> &lt; 0.0001). VASP phosphorylation analysis may be useful for the detection of coronary SAT. Cathet Cardiovasc Intervent 2003;59:295\u2013302. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.10497","type":"journal-article","created":{"date-parts":[[2003,6,19]],"date-time":"2003-06-19T10:13:28Z","timestamp":1056017608000},"page":"295-302","source":"Crossref","is-referenced-by-count":308,"title":["Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator\u2010stimulated phosphoprotein 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