{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:06:51Z","timestamp":1761862011759},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,8,27]],"date-time":"2001-08-27T00:00:00Z","timestamp":998870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dyspnea and arterial desaturation on upright position in elderly subjects is described as platypnea\u2010orthodeoxia syndrome (POS) and in some patients it is due to right\u2010to\u2010left shunt across the atrial septal defect (ASD)\/patent foramen ovale (PFO). Surgical closure of ASD\/PFO has been the only available treatment option. Buttoned device has been used for occlusion of ostium secundum ASD, PFO associated with presumed paradoxical embolism and cerebrovascular accidents and ASD\/PFO in association with other congenital heart defects causing right\u2010to\u2010left shunt. The objective of this article is to describe the use of buttoned device in effectively occluding ASD\/PFO to relieve hypoxemia of POS. During a 4\u2010year period ending January 2000, 10 patients, ages 71 \u00b1 9 (range 60\u201383) years with POS underwent buttoned device closure of their ASD\/PFO. Echocardiographic and balloon\u2010stretched atrial defect sizes were 8 \u00b1 3 mm and 12 \u00b1 3 mm, respectively. The ASD\/PFO were occluded with devices ranging in size from 25 to 40 mm delivered via 9 French, long, blue Cook sheaths; eight had an additional 25\u2010 or 35\u2010mm occluder placed on the right atrial side. The oxygen saturation increased (<jats:italic>P<\/jats:italic> &lt; 0.001) from 76 \u00b1 7% (range 69\u201386%) to 95 \u00b1 2% (range 92\u201398%). No complications were encountered. Relief of symptoms was seen in all patients. Follow\u2010up of 1\u201336 months (median 12 months) revealed persistent improvement of symptoms. Buttoned device occlusion of ASD\/PFO to relieve hypoxemia of POS is feasible, safe, and effective and is an excellent alternative to surgery. Cathet Cardiovasc Intervent 2001;54:77\u201382. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.1243","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:56:46Z","timestamp":1030305406000},"page":"77-82","source":"Crossref","is-referenced-by-count":23,"title":["Platypnea\u2010orthodeoxia: Management by transcatheter buttoned device implantation"],"prefix":"10.1002","volume":"54","author":[{"given":"P. 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