{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:55:48Z","timestamp":1770965748295,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,9,27]],"date-time":"2001-09-27T00:00:00Z","timestamp":1001548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myointimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA) is a key component of the process of restenosis. The c\u2010myc is a critical cell\u2010cycle division protein involved in the formation of neointima. We evaluated the long\u2010term impact of local delivery of c\u2010myc neutrally charged antisense oligonucleotides (Resten\u2010NG) on myointimal hyperplasia after PTCA in a rabbit model. PTCA was performed in the iliac arteries of 25 New Zealand white rabbits, using a Transport\\T catheter at 8 atm for 30 sec, three times; 500 \u03bcg Resten\u2010NG (n = 11) or saline (n = 14) was delivered to the PTCA site at 2 atm with the outer balloon for 2 min. The diet was supplemented with 0.25% cholesterol for 10 days before and 60 days after PTCA. Angiography was performed at harvest, and vessels were fixed in formalin, processed, and stained with hematoxylin and eosin (H&amp;E) and Movat. Quantitative angiography showed that local delivery of antisense c\u2010myc at PTCA reduced late luminal loss from 1.8 \u00b1 0.30 mm in control animals to 0.90 \u00b1 0.30 mm in the treatment group (<jats:italic>P<\/jats:italic> = 0.001). Histological analysis by planimetry showed that intimal areas were 1.67 \u00b1 0.44 mm<jats:sup>2<\/jats:sup> and 0.82 \u00b1 0.32 mm<jats:sup>2<\/jats:sup> in the control and antisense delivery groups, respectively (<jats:italic>P<\/jats:italic> &lt; 0.05). We conclude that local delivery of Resten\u2010NG inhibited myointimal hyperplasia after PTCA in cholesterol\u2010fed rabbits for up to 60 days. Cathet Cardiovasc Intervent 2001;54:247\u2013256. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.1277","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:26:02Z","timestamp":1030310762000},"page":"247-256","source":"Crossref","is-referenced-by-count":18,"title":["Local delivery of c\u2010myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model"],"prefix":"10.1002","volume":"54","author":[{"given":"Nicholas","family":"Kipshidze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eamon","family":"Keane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paramjith","family":"Chawla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Skrinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latha Raja","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Komorowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Haudenschild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Iversen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Keelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Moses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,9,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.2.538"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.70.4.835"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.17.1802"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90712-A"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)91606-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/359067a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8474"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.1.280"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117123"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.76.2.176"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.944"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199707)41:3<348::AID-CCD17>3.0.CO;2-J"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.4.520"},{"key":"e_1_2_1_15_2","first-page":"I\u20101","article-title":"The PREVENT trial of vein graft genetic engineering: preliminary molecular and clinical findings. 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