{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:33:56Z","timestamp":1756992836547},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T00:00:00Z","timestamp":1130284800000},"content-version":"vor","delay-in-days":10160,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet. Cardiovasc. Diagn."],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronary artery spasm (CAS) has been postulated to be a pathophysiologic mechanism in the production of ischemic\u2010like chest pain and ECG changes in patients with idiopathic mitral valve prolapse syndrome. To evaluate the possible role of symptomatic CAS evoked by ergonovine maleate, this agent was administered (0.05 to 0.4 mg IV) to 24 patients with chest pain and mitral valve prolapse who had no significant (&lt;50%) coronary artery obstruction.<\/jats:p><jats:p>Symptoms, ECG and blood pressure changes were monitored in all patients following ergonovine administration. No significant changes were observed in heart rate, systolic blood pressure, or double product. Six patients developed their typical chest pain. In two of these six with chest pain, ST segment shifts &gt;1 mm were seen.<\/jats:p><jats:p>Post\u2010ergonovine left ventricular end\u2010diastolic pressure (LVEDP) and coronary angiographic changes were also studied in a subgroup of 12 of these patients, including five of the six chest pain responders. In the five chest pain responders, pain was associated with a significant rise in LVEDP, whereas no significant change occurred in those patients not experiencing chest pain (p&lt;0.01). Chest pain was also associated with significant CAS (&gt;50% lumen reduction) in two patients, each with ST segment shifts &gt;1 mm.<\/jats:p><jats:p>In summary, ergonovine stimulation failed to evoke symptoms, ECG or blood pressure changes in three quarters of mitral valve prolapse patients studied. Six patients developed chest pain. Chest pain was associated with ECG changes characteristic of CAS in two of these patients, each with angiographic CAS. Thus, symptomatic CAS induced by ergonovine was absent in the majority of these 24 patients with idiopathic mitral valve prolapse syndrome.<\/jats:p>","DOI":"10.1002\/ccd.1810040308","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:35:44Z","timestamp":1172709344000},"page":"265-274","source":"Crossref","is-referenced-by-count":9,"title":["Ergonovine testing for coronary artery spasm in patients with angiographic mitral valve prolapse"],"prefix":"10.1002","volume":"4","author":[{"given":"Michael B.","family":"Sabom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"R. Charles","family":"Curry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard G.","family":"Christie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Richard","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(75)90229-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.1.73"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.54.2.203"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90328-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.48.5.1128"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90808-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.68.5.625"},{"key":"e_1_2_1_9_2","first-page":"II\u201089","article-title":"Pathogenetic mechanism of angina at rest (abstr)","volume":"52","author":"Maseri A","year":"1975","journal-title":"Circulation"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/119.3.521"},{"key":"e_1_2_1_11_2","first-page":"II\u2010173","article-title":"Prinzmetal's angina: ischemia due to spasm (abstr)","volume":"54","author":"Huckell VF","year":"1976","journal-title":"Circulation"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91267-8"},{"key":"e_1_2_1_13_2","first-page":"III\u2010238","article-title":"Spontaneous versus ergonovine induced coronary artery spasm: Clinical and angiographic comparison (abstr)","volume":"65","author":"Curry RC","year":"1977","journal-title":"Circulation"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.48.3.514"},{"key":"e_1_2_1_15_2","first-page":"747","article-title":"Coronary angiography: Potentially serious sources of error in interpretation.","volume":"2","author":"Pepine CJ","year":"1977","journal-title":"Cardiovasc Med"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(70)90134-1"},{"key":"e_1_2_1_17_2","first-page":"430","article-title":"Papillary muscle ischemia with patent coronary arteries.","volume":"78","author":"Brazier JR","year":"1975","journal-title":"Surgery"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.3.490"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.49.4.717"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(77)90060-1"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.56.5.803"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(77)90081-9"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.29.5.739"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5689.139"}],"container-title":["Catheterization and Cardiovascular Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.1810040308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.1810040308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T16:20:17Z","timestamp":1699806017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.1810040308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.1002\/ccd.1810040308"],"URL":"https:\/\/doi.org\/10.1002\/ccd.1810040308","archive":["Portico"],"relation":{},"ISSN":["0098-6569","1097-0304"],"issn-type":[{"value":"0098-6569","type":"print"},{"value":"1097-0304","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]}}}