{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:26:15Z","timestamp":1759332375656},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,24]],"date-time":"2005-10-24T00:00:00Z","timestamp":1130112000000},"content-version":"vor","delay-in-days":9428,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet. Cardiovasc. Diagn."],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of symptom\u2010limited maximal treadmill exercise was evaluated in 34 patients with sickle cell trait (SCT) and 43 controls. Systolic time intervals were measured before and after exercise in 15 of the sickle cell trait subjects, and in 11 controls. Rate pressure product, degree of ST segment depression and incidence of ventricular arrhythmias in subjects with SCT were not significantly different from similar measurements in the control group. No significant difference in electromechanical systole QS<jats:sub>2<\/jats:sub>, left ventricular ejection time (LVET), pre\u2010ejection period (PEP)\/LVET or ejection fraction (EF) were found between the groups. These data indicate that healthy subjects with SCT do not have an increased incidence of exercise\u2010induced ventricular arrhythmias, myocardial ischemia, or diminished ventricular function compared to normals. Further studies are indicated to elucidate factors that may be operative in the sudden death syndrome.<\/jats:p>","DOI":"10.1002\/ccd.1810060109","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:59:38Z","timestamp":1172710778000},"page":"73-80","source":"Crossref","is-referenced-by-count":9,"title":["The risk of sudden death in sickle cell trait: Noninvasive assessment of cardiac response to exercise"],"prefix":"10.1002","volume":"6","author":[{"given":"Charles K.","family":"Francis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis W.","family":"Bleakley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197302082880612"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-77-6-997"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-4-613_2"},{"key":"e_1_2_1_5_2","first-page":"614","article-title":"Risk in sickle cell trait (letter)","volume":"78","author":"Motulsky AG","year":"1973","journal-title":"Ann Intern Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/milmed\/136.1.27","article-title":"How diligently should the diagnoses of sickle cell trait be pursued? Clinical case report with military implication","volume":"136","author":"York E","year":"1971","journal-title":"Milit Med"},{"key":"e_1_2_1_7_2","unstructured":"Ad\u2010Hoc Committee on S\u2010Hemoglobinopathies Division of Medical Sciences National Academy of Science \u2010 National Research Council: The S\u2010Hemoglobinopathies: An evaluation of their status in the Armed Forces. February1973."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.42.3.455"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196011102631905"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-60-3-465"},{"key":"e_1_2_1_11_2","unstructured":"RublerS FleischerA:Sudden death in patients with sickle cell trait associated with cardiomyopathy and pulmonary infarction. Excerpta Medica International Congress Series No. 121 15th International Congress of Internal Medicine. Amsterdam September1966."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197002052820607"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5541.677"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90110-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196103000-00007"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(65)90211-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(69)90027-9"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90403-3"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.3.436"},{"key":"e_1_2_1_20_2","first-page":"241","article-title":"Exercise in sickle cell trait","author":"Ramirez A","year":"1974","journal-title":"Circulation"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.225.8.981"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-44-2-257"}],"container-title":["Catheterization and Cardiovascular Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.1810060109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.1810060109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T14:48:20Z","timestamp":1699800500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.1810060109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["10.1002\/ccd.1810060109"],"URL":"https:\/\/doi.org\/10.1002\/ccd.1810060109","archive":["Portico"],"relation":{},"ISSN":["0098-6569","1097-0304"],"issn-type":[{"value":"0098-6569","type":"print"},{"value":"1097-0304","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}