{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:34:33Z","timestamp":1697776473271},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,25]],"date-time":"2005-10-25T00:00:00Z","timestamp":1130198400000},"content-version":"vor","delay-in-days":7968,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet. Cardiovasc. Diagn."],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to assess the relation between the extent of coronary artery disease (CAD) and size of exercise\u2010induced myocardial hypoperfusion in 79 patients with angiographically documented CAD. None of the patients had Q\u2010wave myocardial infarction. Fifty patients had one\u2010vessel disease, ten had two\u2010vessel disease, and 19 patients had three\u2010vessel or left main disease.<\/jats:p><jats:p>From a scintigraphic functional standpoint, patients were classified into two groups: 28 patients (35%) had large perfusion defects and 51 patients (65%) had small defects. The size of the thallium\u2010201 perfusion defect during exercise was assessed as the perimeter of the defect in each projection expressed as a percentage abnormality of the total left ventricular perimeter in that projection. The average abnormality from the three projections was used in the final analysis. Eleven patients with large defects (39%) had one\u2010vessel disease and 12 patients with small defects (24%) had multivessel disease. Stepwise multivariate discriminate analysis identified the number of diseased vessels (F = 13.9), the change in systolic blood pressure from rest to exercise (F = 10.8), the exercise heart rate (F = 9.1), and exercise electrocardiographic response (F = 7.8) as significant associates of the size of the perfusion defect (predictive accuracy = 70%).<\/jats:p><jats:p>We conclude that the size of hypoperfused myocardium during exercise is variable in patients with CAD. Discriminate analysis identified the extent of CAD, exercise heart rate, change in systolic pressure from rest to exercise, and exercise electrocardiographic response as significant associates of the size of the defect.<\/jats:p>","DOI":"10.1002\/ccd.1810100402","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:25:57Z","timestamp":1172748357000},"page":"311-318","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of patients with coronary artery disease during exercise: The relation between extent of disease and perfusion deficit"],"prefix":"10.1002","volume":"10","author":[{"given":"A\u2010Hamid","family":"Hakki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Depace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmassih 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