{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T09:01:03Z","timestamp":1767085263569},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,10,25]],"date-time":"2005-10-25T00:00:00Z","timestamp":1130198400000},"content-version":"vor","delay-in-days":6568,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet. Cardiovasc. Diagn."],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To analyze the behavior of aortic valve gradient (AVG) after ventricular extrasystole (VE), we studied 36 pure valvular aortic stenoses (AS) free of coronary artery disease and obstructive hypertrophic cardiomyopathy, in whom basal (B) (74 \u00b1 32 mm Hg) and catheter\u2010induced post\u2010VE (110 \u00b1 50 mm Hg) AVG were obtained. In all 26 cases with valve area &lt;0.70 cm<jats:sup>2<\/jats:sup>, the post\u2010VE AVG was \u226570 mm Hg. In 19 cases AVG after two or more consecutive VE were also obtained. Maximal post\u2010VE AVG was obtained after multiple VE (19 cases) and\/or after one VE causing a post\u2010VE pause equal or longer than 1.7 basal cardiac cycles (post\u2010VE RR \u22651.7B RR) (9 cases). Basal and postsingle VE AVG, up to a post\u2010VE RR \u2265 1.7 B RR, were a linear function of previous RR (r\u22650.90), regression line slope increasing with AS severity (<jats:italic>P<\/jats:italic> =.05). Inotropic state measured by PEP\/LVET only increased after multiple VE, <jats:italic>P<\/jats:italic> &lt;.01. AVG after multiple VE was independent of post\u2010VE RR. Thus, (1) post\u2010VE potentiation of AVG may be seen with fixed valvular AS without obstructive cardiomyopathy; (2) post\u2010VE AVG is a function of compensatory pause after single VE and of increased inotropism after multiple VE; (3) analysis of maximal post\u2010VE AVG generated as described is reliable and useful for assessing AS severity (post\u2010VE AVG \u2265 70 mm Hg meaning an aortic valve area &lt;0.70 cm<jats:sup>2<\/jats:sup>) and may supplement valve area calculations.<\/jats:p>","DOI":"10.1002\/ccd.1810130604","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:48:17Z","timestamp":1172753297000},"page":"381-390","source":"Crossref","is-referenced-by-count":6,"title":["Postextrasystolic potentiation of systolic gradient in valvular aortic stenosis: Clinical usefulness and analysis of hemodynamic factors"],"prefix":"10.1002","volume":"13","author":[{"given":"Enric","family":"Domingo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Angel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inocencio","family":"Anivarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Soler\u2010Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,25]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"LagendorffO:Veber elektrische Reizung des Herzens. 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