{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T12:01:31Z","timestamp":1722772891463},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,25]],"date-time":"2005-10-25T00:00:00Z","timestamp":1130198400000},"content-version":"vor","delay-in-days":5046,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet. Cardiovasc. Diagn."],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010three children with cyanotic congenital heart defects, aged 3 days to 11.5 years, weighing 2.9 to 30 kg, underwent percutaneous balloon pulmonary valvuloplasty to improve pulmonary oligemia. The patients were divided into two groups: group I with intact ventricular septum and group II with ventricular septal defect. In 12 group I patients, there was an increase of systemic arterial oxygen saturation [83 \u00b1 8% (mean \u00b1 SD) vs. 94 \u00b1 5%, P &lt; 0.001] and pulmonary\u2010to\u2010systemic flow ratio (0.7 \u00b1 0.1 vs. 1.0 \u00b1 0.2, P &lt; 0.001). Peak systolic pressure gradient across the pulmonary valve decreased (P &gt; 0.001) from 105 \u00b1 48 to 25 \u00b1 18 mm Hg. In 11 group II patients, arterial oxygen saturation (67 \u00b1 13 vs. 83 \u00b1 13%, P &lt; 0.01) and pulmonary\u2010to\u2010systemic flow ratio (0.7 \u00b1 0.4 vs. 1.2 \u00b1 0.5, P &lt; 0.02) increased following valvuloplasty. Peak systolic pressure gradient across the pul\u2010monic valve (52 \u00b1 16 vs. 32 \u00b1 22 mm Hg, P &lt; 0.05) decreased while infundibular and total pulmonary outflow tract gradients were unchanged (P &gt; 0.1). Immediate surgical intervention was avoided in all cases in both groups. On follow\u2010up, 1 to 36 months after valvuloplasty, arterial oxygen saturation, pulmonary\u2010to\u2010systemic flow ratio, and pulmonary valve gradients remain improved in both groups. However, in group I, repeat balloon valvuloplasty was required in two children. In group II, six children with tetralogy of Fallot (TOF) underwent successful total surgical correction 4 months to 2 years after valvuloplasty. Two children with transposition of the great arteries required Blalock\u2010Taussig shunts 6 and 18 months after valvuloplasty for further improvement of hypoxemia. Demonstrable increase in pulmonary artery diameter occurred in several children. These data suggest that pulmonary valvuloplasty offers an excellent relief of pulmonary valve obstruction in the intact ventricular septum group and palliation of pulmonary oligemia in the ventricular septal defect group. In the latter group, avoiding immediate surgical shunts in all patients and achieving growth in pulmonary arterial size in many patients, thus making them suitable for further surgical palliation or correction, are additional advantages.<\/jats:p>","DOI":"10.1002\/ccd.1810250105","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:53:58Z","timestamp":1172793238000},"page":"16-24","source":"Crossref","is-referenced-by-count":28,"title":["Balloon pulmonary valvuloplasty in the management of cyanotic congenital heart defects"],"prefix":"10.1002","volume":"25","author":[{"given":"P. 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