{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:53:57Z","timestamp":1715579637889},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T00:00:00Z","timestamp":1134000000000},"content-version":"vor","delay-in-days":3963,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet. Cardiovasc. Diagn."],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prolonged intravascular infusion of urokinase has proven beneficial in reestablishing patency of chronically occluded peripheral arteries and saphenous vein grafts. This study was performed to assess the efficacy and safety of prolonged urokinase infusions as a prelude to angioplasty in chronically occluded native coronary arteries, that had failed standard angioplasty techniques. Twenty\u2010five patients with objective evidence for ischemia in the distribution of a chronic coronary occlusion were referred for percutaneous intervention. Patients were assessed for any potential exclusions from lytic therapy. Urokinase infusion through both a SOS wire and a stable guiding catheter was continued at 100,00\u2013240,000 units\/hr for 8\u201325 hr; patents then underwent attempted balloon angioplasty. Mean duration of urokinase infusion was 20.6 \u00b1 7.7 hr (total dose 163,000 \u00b1 52,447 units\/hr). Fibrinogen levels dropped slightly with this (300 \u00b1 129 to 203 \u00b1 81 mg\/dl, <jats:italic>P<\/jats:italic> = 0.02). Angiography posturokinase showed improvement in 7 (28%) with regard to coronary flow (\u00b1 1 TIMI\u2010grade). Angioplasty was successful in 13 (52%), with final angiographic result revealing thrombus in 5 (20%), or dissection 8 (32%). The infusions were well\u2010tolerated with a low incidence of chest pain, 2 (8%); or ischemic ECG response, 2 (8%); myocardial infarction, 2 (8%); or significant bleeding 2 (8%). All patients survived the procedure, with a length\u2010of\u2010hospital stay = 5.1 \u00b1 4 days. Use of prolonged preangioplasty intracoronary urokinase infusion can be done safely with success in roughly one\u2010half of patients with chronic total native coronary occlusions who have failed prior attempts at percutaneous intervention. A larger more rigorously designed protocol is required to make specific recommendations about technique, cost, and long\u2010term follow\u2010up.<\/jats:p>","DOI":"10.1002\/ccd.1810340405","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T06:49:21Z","timestamp":1172818161000},"page":"106-110","source":"Crossref","is-referenced-by-count":7,"title":["Prolonged urokinase infusion for chronic total native coronary occlusions: Clinical, angiographic, and treatment observations"],"prefix":"10.1002","volume":"34","author":[{"given":"Steven C.","family":"Ajluni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Zidar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Puchrowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Margulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy L.","family":"Grines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80263-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80108-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehjsup.2004.06.005"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90630-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91164-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(88)80028-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90285-W"},{"issue":"4","key":"e_1_2_1_9_2","first-page":"II","article-title":"Angioplasty of chronic occlusions: Risks and benefits","volume":"84","author":"Stewart JT","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.1.106"},{"issue":"4","key":"e_1_2_1_11_2","first-page":"III","article-title":"Magnum\/magnarail versus conventional systems for recanalization of chronic total coronary occlusions\u2010a randomized comparison","volume":"82","author":"Meier B","year":"1990","journal-title":"Circulation"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90678-R"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90684-2"},{"issue":"4","key":"e_1_2_1_14_2","first-page":"11","article-title":"Improvement in left ventricular function following PTCA to chronic totally occluded arteries","volume":"84","author":"Anderson TJ","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810280304"},{"key":"e_1_2_1_16_2","first-page":"250","article-title":"Selective tissue plasminogen activator infusion for chronic total occlusions of native coronary arteries failing angioplasty","volume":"84","author":"Vaska KJ","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_1_17_2","first-page":"IV","article-title":"Acute complications following coronary angioplasty of totally occluded vessels","volume":"76","author":"Andreas GE","year":"1987","journal-title":"Circulation"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)91420-J"}],"container-title":["Catheterization and Cardiovascular Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.1810340405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.1810340405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:58:40Z","timestamp":1698263920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.1810340405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["10.1002\/ccd.1810340405"],"URL":"https:\/\/doi.org\/10.1002\/ccd.1810340405","archive":["Portico"],"relation":{},"ISSN":["0098-6569","1097-0304"],"issn-type":[{"value":"0098-6569","type":"print"},{"value":"1097-0304","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2]]}}}