{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:42:19Z","timestamp":1698309739904},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T00:00:00Z","timestamp":1130284800000},"content-version":"vor","delay-in-days":3800,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet. Cardiovasc. Diagn."],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b2\u2010blocker therapy for mitral stenosis is controversial. This study compares right and left heart hemodynamics at rest and supine submaximal exercise in patients (n = 7) receiving chronic \u03b2\u2010antagonists with untreated patients (n = 17) matched for age (mean \u00b1 SD = 51 \u00b1 12 years) and valve area (0.7 \u00b1 0.2 cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>). Little benefit was observed with treatment at rest. Although pulmonary capillary wedge pressures (PCWP) were lower during exercise in the \u03b2\u2010blocker group (22\u00b14 vs. 31 \u00b1 9 mmHg; <jats:italic>P<\/jats:italic>&gt;0.05), exercise performance was not enhanced and cardiac output response during exercise was reduced (control = 41% increase vs. 12% for \u03b2\u2010blockade). PCWP rose rapidly when diastolic filling periods were &gt;300 msec in both groups. Pulmonary capillary wedge pressure was found to be a nonlinear functions (<jats:italic>P<\/jats:italic>&lt;0.001) of diastolic filling period (PCWP = 15.9 + 5.84 \u00d7 10<jats:sup>5<\/jats:sup>\/dfp<jats:sup>2<\/jats:sup>). These data suggest that there is a critical heart rate in patients with mitral stenosis above which hemodynamic compromise rapidly occurs. \u00a9 1995 Wiley\u2010Liss, Inc.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#note1\" \/><jats:fn><jats:p>This article is a US Government work and, as such, is in the public domain in the United States of America.<\/jats:p><\/jats:fn>\n<\/jats:p>","DOI":"10.1002\/ccd.1810350206","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T06:48:31Z","timestamp":1172818111000},"page":"110-115","source":"Crossref","is-referenced-by-count":6,"title":["Effects of chronic \u03b2\u2010blockade on rest and exercise hemodynamics in mitral stenosi"],"prefix":"10.1002","volume":"35","author":[{"given":"Thomas L.","family":"Ashcom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Johns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard J.","family":"Rubal PhD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(77)80207-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90172-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.30.2.188"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)91018-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.34.6.638"},{"key":"e_1_2_1_7_2","first-page":"527","article-title":"Hemodynamic response to exercise after beta\u2010adrenergic blockade with propranolol in patients with mitral valve obstruction","volume":"95","author":"Cummings GR","year":"1966","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.58.3.254"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(51)90002-6"},{"key":"e_1_2_1_10_2","first-page":"306","volume-title":"Cardiac Catheterization and Angiography","author":"Grossman W","year":"1986"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.11.4.531"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.42.6.1099"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90172-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(51)90099-3"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(51)90003-8"},{"key":"e_1_2_1_16_2","first-page":"175","article-title":"Effecto del propranolol sobre la capacidad functional en la estenosis mitral no complicada","volume":"2","author":"Penas M","year":"1981","journal-title":"Rev Lat Cardiol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.67.1.148"}],"container-title":["Catheterization and Cardiovascular Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.1810350206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.1810350206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T21:55:33Z","timestamp":1698270933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.1810350206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1002\/ccd.1810350206"],"URL":"https:\/\/doi.org\/10.1002\/ccd.1810350206","archive":["Portico"],"relation":{},"ISSN":["0098-6569","1097-0304"],"issn-type":[{"value":"0098-6569","type":"print"},{"value":"1097-0304","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}