{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:08:05Z","timestamp":1700179685440},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T00:00:00Z","timestamp":1111536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sirolimus systemic administration has shown marked inhibition of neointimal hyperplasia (NIH) after balloon angioplasty in porcine models. In this pilot study, we tested the hypothesis that oral sirolimus is safe and effective to inhibit in\u2010stent NIH and therefore to prevent and treat in\u2010stent restenosis (ISR). Twelve patients (18 lesions) with high risk for ISR, including 8 ISR lesions, were admitted. One day before the procedure, patients were given a 15 mg loading dose of oral sirolimus, followed by 5 mg daily for 28 days, with weekly whole blood level measurements. The daily dose was adjusted to keep the concentration at 10\u201315 ng\/ml. Sirolimus was well tolerated by all patients but one, who died at the end of the third week of treatment. The 4\u2010 and 8\u2010month follow\u2010up revealed an angiographic late loss of 0.40 \u00b1 0.24 and 0.67 \u00b1 0.45 mm (<jats:italic>P<\/jats:italic> &lt; 0.01), respectively. At the same time points, the intravascular ultrasound in in\u2010stent relative volumetric obstruction was 14.4% \u00b1 9.1% and 23.2% \u00b1 10.1% (<jats:italic>P<\/jats:italic> &lt; 0.01), respectively. At 24\u2010month clinical follow\u2010up, adverse events were one (8.3%) death, two (11.1%) target lesion, and four (22.2%) target vessel revascularizations. In conclusion, in this small group of high\u2010risk ISR patients, oral sirolimus inhibited NIH and therefore may be an effective strategy for the prevention and treatment of ISR. Catheter Cardiovasc Interv 2005;64:413\u2013418. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.20332","type":"journal-article","created":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T23:20:54Z","timestamp":1111620054000},"page":"413-418","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of oral sirolimus to inhibit in\u2010stent intimal hyperplasia"],"prefix":"10.1002","volume":"64","author":[{"suffix":"Jr.","given":"F\u00e1bio S.","family":"Brito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werther C.M.","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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