{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:30:49Z","timestamp":1787729449286,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T00:00:00Z","timestamp":1134000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was conducted to assess the systemic drug release and distribution of sirolimus\u2010eluting stents. Early results with sirolimus\u2010eluting stents have demonstrated a favorable outcome for reducing restenosis post coronary intervention. However, the clinical systemic pharmacokinetics of sirolimus released from these stents has not been investigated. Sirolimus\u2010eluting stents (150\u2013178 mcg\/18 mm stent) were implanted in 19 patients with coronary artery disease using standard techniques. Blood samples were obtained at multiple times to determine the kinetics of sirolimus release and elimination. Non\u2010compartmental analysis showed that the maximum blood concentration of sirolimus occurred between 3 and 4 hr after implantation, with a peak concentration of 0.57 \u00b1 0.12 ng\/mL (mean \u00b1 SD) and 1.05 \u00b1 0.39 ng\/mL in patients receiving one or two stents, respectively. Terminal\u2010phase elimination half\u2010life was independent of the number of stents and averaged at 213 hr, a value longer than that seen in patients following oral dosing. The apparent clearance was 1.46 \u00b1 0.45 L\/hr with an apparent volume of distribution in the terminal phase of 407 \u00b1 111 L (data for both stent doses pooled). Minimal measurable blood levels were detectable at 7 days. Peak whole blood level following sirolimus stent implantation in humans is proportional to the number of stents implanted. The prolonged terminal half\u2010life may reflect kinetics of blood clearance combined with continued drug elution and secondary local tissue release. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.20565","type":"journal-article","created":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T02:16:25Z","timestamp":1134094585000},"page":"32-37","source":"Crossref","is-referenced-by-count":40,"title":["Sirolimus PK trial: A pharmacokinetic study of the sirolimus\u2010eluting Bx Velocity stent in patients with de novo coronary lesions"],"prefix":"10.1002","volume":"67","author":[{"given":"George W.","family":"Vetrovec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rizik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark","family":"Williard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Snead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Piotrovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kopia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.2.192"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012843"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000051720.59095.6D"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00222-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02480-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00230-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3601.093987"},{"issue":"6","key":"e_1_2_6_9_2","first-page":"117H","article-title":"Sirolimus\u2010eluting stents: antirestenosis efficacy vs. local and systemic pharmacokinetics in a porcine coronary model","volume":"90","author":"Kopia GA","year":"2002","journal-title":"Am J Cardiol"},{"key":"e_1_2_6_10_2","first-page":"355","article-title":"The sirolimus PK trial: a pharmacokinetic study of the sirolimus\u2010eluting Bx Velocity stent in patients with de novo coronary lesions","volume":"106","author":"Vetrovec GW","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1201\/b14095","volume-title":"Pharmacokinetics","author":"Gibaldi M","year":"1982"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200205000-00008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199302000-00021"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1997.tb04318.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(00)89027-X"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.1996.100"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199708000-00007"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.20565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.20565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T19:15:33Z","timestamp":1697483733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.20565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,8]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/ccd.20565"],"URL":"https:\/\/doi.org\/10.1002\/ccd.20565","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,8]]}}}