{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:00:23Z","timestamp":1768586423060,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T00:00:00Z","timestamp":1149724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:styled-content>Objective:<\/jats:styled-content><\/jats:title><jats:p>To assess the effect of irinotecan\u2010eluting stents (IS) on neointimal growth in the aortas of hypercholesterolemic rabbits and to determine other local histopathological effects such as necrosis, fibrin, and inflammatory reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:styled-content>Methods<\/jats:styled-content>:<\/jats:title><jats:p>Phosphorylcholine\u2010coated stents were deployed in the aortas of hypercholesterolemic rabbits. Group 1 (control; <jats:italic>n<\/jats:italic> = 8) received unloaded stents, group 2 (<jats:italic>n<\/jats:italic> = 7) and group 3 (<jats:italic>n<\/jats:italic> = 9) received IS with 0.046 mg and 1.29 mg of irinotecan, respectively. Eight weeks after implantation the rabbits were killed. Neointimal thickness (NT) was assessed by morphometry. Semiquantitative injury score (from 0 to 3+) was used to analyze inflammatory infiltrate, fibrin deposits, and necrosis in the stented segments.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:styled-content>Results<\/jats:styled-content>:<\/jats:title><jats:p>NT was reduced only in high\u2010doses IS (G1, 167.4 \u00b1 20.8 \u03bc; G2, 170.24 \u00b1 21.2 \u03bc; G3, 111.56 \u00b1 12.7 \u03bc; <jats:italic>P<\/jats:italic> &lt; 0.05, G3 vs G1 and G2). Necrosis decreased significantly with IS [1.00 \u00b1 0.10 in G1 to 0.33 \u00b1 0.07 and 0.02 \u00b1 0.01 in G2 and G3, respectively] only in the media layer. The inflammatory infiltrate was present in the three layers of aortas from G1, but only decreased significantly in the intimae layer of the high\u2010dose group [1.50 \u00b1 0.15 in G1 vs 1.00 \u00b1 0.18 in G3, <jats:italic>P<\/jats:italic> &lt; 0.05].<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:styled-content>Conclusion<\/jats:styled-content>:<\/jats:title><jats:p>Stents loaded with high\u2010dose irinotecan inhibit NT in the aortas of hypercholesterolemic rabbits. This effect was accompanied by decreased inflammatory infiltrate and media necrosis. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.20694","type":"journal-article","created":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T22:31:06Z","timestamp":1149805866000},"page":"89-96","source":"Crossref","is-referenced-by-count":4,"title":["Irinotecan\u2010eluting stents inhibited neointimal proliferation in hypercholesterolemic rabbit aortas"],"prefix":"10.1002","volume":"68","author":[{"given":"Daniel H.","family":"Berrocal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n E.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo 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