{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T08:30:25Z","timestamp":1781425825771,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:00:00Z","timestamp":1151625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives:<\/jats:styled-content> We wished to determine the feasibility and early safety of external beam radiation therapy (EBRT) used following balloon aortic valvuloplasty (BAV) to prevent restenosis. <jats:styled-content>Background:<\/jats:styled-content> BAV for calcific aortic stenosis (AS) has been largely abandoned because of high restenosis rates, i.e., &gt; 80% at 1 year. Radiation therapy is useful in preventing restenosis following vascular interventions and treating other benign noncardiovascular disorders. <jats:styled-content>Methods:<\/jats:styled-content> We conducted a 20\u2010patient, pilot study evaluating EBRT to prevent restenosis following BAV in elderly patients with calcific AS. Total doses ranging from 12\u201318 Gy were delivered in fractions over a 3\u20135 day post\u2010op period to the aortic valve. Echocardiography was performed pre and 2 days post\u2010op, 1, 6, and 12 months following BAV. <jats:styled-content>Results:<\/jats:styled-content> One\u2010year follow\u2010up is completed (age 89 \u00b1 4). There were no complications related to EBRT. Eight patients died prior to 1 year; 5 of 10 (50%) in the low\u2010dose (12 Gy) group and 3 of 10 (30%) in the high\u2010dose (15\u201318 Gy) group. None of these 8 patients had restenosis, i.e., &gt; 50% loss of the initial AVA gain, and only three deaths were cardiac in origin. One patient underwent aortic valve replacement and none repeated BAV. By 1 year, 3 of the initial 10 (30%) in the low\u2010dose group and 1 of 9 (11%) in the high\u2010dose group demonstrated restenosis (21% overall). <jats:styled-content>Conclusions:<\/jats:styled-content> EBRT following BAV in elderly patients with AS is feasible, free of early complications, and holds promise in reducing the 1 year restenosis rate in a dose\u2010dependent fashion. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.20818","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T15:25:20Z","timestamp":1151681120000},"page":"183-192","source":"Crossref","is-referenced-by-count":18,"title":["Radiation following percutaneous balloon aortic valvuloplasty to prevent restenosis (RADAR pilot trial)"],"prefix":"10.1002","volume":"68","author":[{"given":"Wes R.","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Van 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