{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:45:22Z","timestamp":1784241922000,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T00:00:00Z","timestamp":1160611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives:<\/jats:styled-content> To assess the safety and efficacy of sirolimus\u2010eluting stents (SESs) in the treatment of severe intermittent claudication and critical limb ischaemia with \u201cbelow\u2010the\u2010knee\u201d lesions, unsuitable for surgery. <jats:styled-content>Background:<\/jats:styled-content> Limited published evidence suggests that drug\u2010eluting stents may offer significant improvements in the treatment of infrapopliteal lesions. <jats:styled-content>Methods:<\/jats:styled-content> Thirty consecutive patients with either severe intermittent claudication or critical limb ischemia (CLI), category 3\u20136 of Rutherford classification, and multivessel disease of infrapopliteal arteries (\u22652 vessels) were treated with SES. Sixty\u2010two arteries were treated with 106 SES. Mean age was 73.9 years, 77% of patients were male and 36% diabetic. The primary endpoint was clinical improvement and healing of ulcers at short term (1 month) and mid term (7.7 months). The secondary endpoint was primary vessel patency rate (angiographic or duplex assessment). All patients received clopidogrel (75 mg daily) or ticlopidine (150 mg daily) for 2 months or longer. <jats:styled-content>Results:<\/jats:styled-content> Angiographic and procedural success was achieved in all patients. At 7 months (7.7 \u00b1 5.8), it was necessary to amputate 1 toe in one patient and 1 mid\u2010foot in another. Limb salvage was obtained in 100% of patients. Other events were: two cardiac deaths unrelated to CLI, one stroke with hemiparesia, one initial reperfusion syndrome, one contralateral CLI, and three recurrent homolateral claudication cases. All surviving patients had a mid\u2010term clinical improvement with 97% of primary patency (56 patent arteries on 58 arteries). <jats:styled-content>Conclusion:<\/jats:styled-content> Treatment of \u201cbelow\u2010the\u2010knee\u201d lesions with SES may provide an alternative treatment for patients with CLI. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.20893","type":"journal-article","created":{"date-parts":[[2006,10,13]],"date-time":"2006-10-13T02:13:12Z","timestamp":1160705592000},"page":"793-798","source":"Crossref","is-referenced-by-count":77,"title":["Sirolimus for below the knee lesions: Mid\u2010term results of SiroBTK study"],"prefix":"10.1002","volume":"68","author":[{"given":"Philippe","family":"Commeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Barragan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre O.","family":"Roquebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","article-title":"TransAtlantic Inter\u2010Society Consensus (TASC)","volume":"31","author":"Dormandy JA","year":"2000","journal-title":"J Vasc Surg"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.3026"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-5096(07)60040-5"},{"key":"e_1_2_6_5_2","first-page":"1","article-title":"Second European consensus document on chronic critical leg ischemia","volume":"84","author":"The European Working Group on Critical Leg Ischemia","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_6_6_2","first-page":"75","article-title":"Critical limb ischemia: A global epidemic. 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