{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:49:49Z","timestamp":1761947389896},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,28]],"date-time":"2006-12-28T00:00:00Z","timestamp":1167264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2007,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: Hemodynamic effects of surgical and percutaneous closure of atrial septal defect (ASD) were evaluated. <jats:styled-content>Background<\/jats:styled-content>: ASD causes volume overload of right ventricle (RV) and is associated with distortion and dysfunction of left ventricle (LV). The amount and timing of hemodynamic changes after ASD closure are not well known. <jats:styled-content>Methods<\/jats:styled-content>: The study group consisted of 7 children treated surgically and 17 treated in the catheterization laboratory. In the control group, there were 51 healthy children. RV size and LV end\u2010diastolic and systolic dimensions, volumes, and function were examined by two\u2010 and three\u2010 dimensional echocardiography and serum concentrations of natriuretic peptides measured prior to ASD closure, and 1, 6, and 12 months thereafter. <jats:styled-content>Results<\/jats:styled-content>: In all children with ASD, during the 1\u2010year follow\u2010up, the <jats:italic>z<\/jats:italic> score of RV end\u2010diastolic diameter decreased from a median 5.00 SD to 2.25 SD (<jats:italic>P<\/jats:italic> &lt; 0.001). Dilatation of RV did not resolve entirely during 1\u2010year follow\u2010up in either treatment group. End\u2010diastolic LV diameter increased from \u22121.50 to \u22120.50 SD (<jats:italic>P<\/jats:italic> &lt; 0.001). LV size increased slower in the surgical subgroup but reached control levels in both groups. Concentrations of natriuretic peptides increased during the first month after ASD closure and normalized thereafter in patients treated percutaneously but remained higher than in controls in patients treated surgically. <jats:styled-content>Conclusions<\/jats:styled-content>: During 1\u2010year follow\u2010up after ASD closure, RV size decreases but does not normalize in all patients. The size of the LV normalizes after ASD closure but the increase in LV size is slower in patients treated surgically. Serum levels of ANPN and proBNP are elevated prior to ASD closure but decrease thereafter to control levels in patients treated with the percutaneous technique but not in those treated surgically. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.20962","type":"journal-article","created":{"date-parts":[[2006,12,28]],"date-time":"2006-12-28T23:48:08Z","timestamp":1167349688000},"page":"432-441","source":"Crossref","is-referenced-by-count":14,"title":["Hemodynamic improvement is faster after percutaneous ASD closure than after surgery"],"prefix":"10.1002","volume":"69","author":[{"given":"Anneli","family":"Eerola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana I.","family":"Pihkala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talvikki","family":"Boldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka P.","family":"Mattila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuija","family":"Poutanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Jokinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,28]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"31","volume-title":"The Natural and Modified History of congenital Heart Disease","author":"Veldtman GR","year":"2004"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.32.6.820"},{"key":"e_1_2_5_4_2","first-page":"171","article-title":"Application of a mechanical heart and lung apparatus to cardiac surgery","volume":"37","author":"Gibbon JH","year":"1954","journal-title":"Minn Med"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1001\/jama.1976.03260490024013","article-title":"Secundum atrial septal defect. 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