{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:27:59Z","timestamp":1774978079470,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T00:00:00Z","timestamp":1171238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>We investigated the prevalence of migraine in patients with patent foramen ovale (PFO), and the effect of PFO closure on migraine symptoms and medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background:<\/jats:title><jats:p>Studies have shown an association between migraine and PFO. Data have recently suggested a reduction in migraine symptoms following PFO closure. Most of these studies had no controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Subjects were divided into three groups: No PFO (Controls, <jats:italic>n<\/jats:italic> = 65), PFO with no intervention (\u201cOpen PFO\u201d, <jats:italic>n<\/jats:italic> = 63), and PFO treated with percutaneous closure (\u201cClosed PFO\u201d, <jats:italic>n<\/jats:italic> = 41). We measured the frequency, severity, and impact of migraine on quality of life employing MIDAS scores. Comparisons were made preceding and 90 days after either transesophageal echocardiography (Controls and \u201cOpen PFO\u201d) or PFO closure (\u201cClosed PFO\u201d). We compared the use of abortive medications between the two time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Migraine, especially with aura, was more prevalent in both PFO groups (<jats:italic>P<\/jats:italic> &lt; 0.05). Migraine frequency was reduced by 83% in Closed PFO compared with 0% of Open PFO and 10% of control patients (<jats:italic>P<\/jats:italic> &lt; 0.0001). Migraine severity and MIDAS scores were reduced by PFO closure when compared to the other two groups (<jats:italic>P<\/jats:italic> &lt; 0.0001, <jats:italic>P<\/jats:italic> = 0.035 respectively). Reduction in abortive medications was noted in 71% after closure, 5% of Open PFO, and 10% of Controls (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In this controlled study, migraine, especially with aura, is more frequent in subjects with PFO. PFO closure is associated with a reduction in migraine frequency and severity, as well as an improvement in MIDAS scores. PFO closure was associated with a significant reduction in the use of abortive medications. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.21025","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T00:26:29Z","timestamp":1171326389000},"page":"740-746","source":"Crossref","is-referenced-by-count":52,"title":["Is patent foramen ovale closure effective in reducing migraine symptoms? A controlled study"],"prefix":"10.1002","volume":"69","author":[{"given":"Carey","family":"Kimmelstiel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Gange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,12]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"89","article-title":"The prevalence of patent foramen ovale in patients with migraine","volume":"38","author":"Domitrz I","year":"2004","journal-title":"Neurol Neurochir Pol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.8.1622"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000015875"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000093236"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03160-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8183.2003.08002.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.022"},{"key":"e_1_2_6_9_2","first-page":"1","article-title":"The international classification of headache disorders, 2nd edition","volume":"24","author":"Olesen J","year":"2004","journal-title":"Cephalalgia"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.988"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047758"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000120677.64217.A9"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000120756.25236.37"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.075"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.055"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60336-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.suppl_1.S4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20699"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000199082.07317.43"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00363.x"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.21025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.21025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T10:35:49Z","timestamp":1697020549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.21025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,12]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1002\/ccd.21025"],"URL":"https:\/\/doi.org\/10.1002\/ccd.21025","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,12]]}}}