{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:50:00Z","timestamp":1761947400908},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T00:00:00Z","timestamp":1172188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Multiple percutaneous therapies for the treatment of functional and ischemic mitral regurgitation (FMR\/IMR) are under development. We previously reported a novel percutaneous technique, the percutaneous septal sinus shortening [PS<jats:sup>3<\/jats:sup>] System\u2122, which was effective in ameliorating FMR in an animal model. We herein report results from the first\u2010in\u2010human safety and feasibility pilot study involving the PS<jats:sup>3<\/jats:sup> System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results:<\/jats:title><jats:p>The primary objective of this first\u2010in\u2010human study was to evaluate the safety and feasibility of acute percutaneous septal\u2010lateral shortening by using the PS<jats:sup>3<\/jats:sup> System in patients immediately prior to clinically\u2010indicated surgical mitral valve repair. Two patients were enrolled. Patient One had severe aortic insufficiency with moderate functional mitral regurgitation. The PS<jats:sup>3<\/jats:sup> System reduced the MR grade from 2+ to 1+ with a decrease in the mean septal\u2010lateral systolic (SLS) dimension from 38 to 27 mm (29% reduction). Patient Two had severe ischemic mitral regurgitation in the setting of severe multi\u2010vessel disease and prior infero\u2010posterior infarct. MR grade was reduced from 3+ to 1+ with a decrease in the mean SLS dimension from 36 to 25mm (31% reduction). There were no procedural complications and both patients proceeded to pre\u2010planned cardiac surgery, where the devices were explanted under direct visualization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The PS<jats:sup>3<\/jats:sup> System has been safely translated from the preclinical setting to first\u2010in\u2010human implantation. Both patients studied experienced a reduction in MR after device implantation, with significant SLS shortening. Further clinical trials will be needed to assess long\u2010term efficacy and durability. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.21070","type":"journal-article","created":{"date-parts":[[2007,2,24]],"date-time":"2007-02-24T08:38:57Z","timestamp":1172306337000},"page":"513-518","source":"Crossref","is-referenced-by-count":27,"title":["Safety and feasibility of acute percutaneous septal sinus shortening: First\u2010in\u2010human experience"],"prefix":"10.1002","volume":"69","author":[{"given":"Igor F.","family":"Palacios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Condado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaston","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginald I.","family":"Low","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason H.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)39144-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90455-V"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90865-A"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1999"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.3.498"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70282-X"},{"key":"e_1_2_5_8_2","first-page":"536","article-title":"Mitral valve reconstruction and replacement for ischemic mitral insufficiency: Seven years' follow up","volume":"8","author":"Hausmann H","year":"1999","journal-title":"J Heart Valve Dis"},{"issue":"1","key":"e_1_2_5_9_2","first-page":"II116","article-title":"Geometric distortions of the mitral valvular\u2010ventricular complex in chronic ischemic mitral regurgitation","volume":"108","author":"Tibayan FA","year":"2003","journal-title":"Circulation"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc37t1.094913"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.122296"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.09.036"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.601518"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.609883"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2005.05.013"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20810"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.591602"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.21070","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.21070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:19:03Z","timestamp":1700007543000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.21070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,23]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1002\/ccd.21070"],"URL":"https:\/\/doi.org\/10.1002\/ccd.21070","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,23]]}}}