{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:20:58Z","timestamp":1789593658914,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T00:00:00Z","timestamp":1198108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objective:<\/jats:styled-content> We report our experience with the elective placement of below\u2010knee, drug\u2010eluting stents in patients with chronic limb ischemia. <jats:styled-content>Background:<\/jats:styled-content> Infrapopliteal percutaneous transluminal angioplasty has been associated with a lower rate of procedural success and high rate of restenosis because of the small size of the tibial vessels and the prevalence of calcified and diffuse atherosclerotic disease. Prior published data reports 3\u2010year patency rates below 25%. Bare metal stents have been reported in bailout situations. Drug\u2010eluting stents have markedly reduced restenosis compared to bare metal stents in the coronary vasculature, but there is little data supporting the use of these devices below the knee. <jats:styled-content>Methods:<\/jats:styled-content> Elective placement of drug\u2010eluting stents in infrapopliteal lesions was performed on 10 patients with severe (\u2265Fontaine Stage IIb) claudication (<jats:italic>n<\/jats:italic> = 1) or limb\u2010threatening ischemia (<jats:italic>n<\/jats:italic> = 9) (rest pain, nonhealing ulcers and gangrene). <jats:styled-content>Results:<\/jats:styled-content> A total of 17 drug\u2010eluting stents were electively placed in 12 below\u2010knee arteries in 10 patients, resulting in an average of 1.7 \u00b1 0.7 stents per patient. The mean lesion length was 24.8 \u00b1 10.9 mm, the mean total stent length was 38.3 \u00b1 19.1 mm, and the mean nominal stent diameter was 2.8 \u00b1 0.3 mm. One patient required target vessel revascularization (TVR) at 3 weeks because of stent thrombosis. TVR was 10% at 12.4 \u00b1 6.5 months of follow\u2010up. Clinically driven angiography in three different patients was performed at 4, 15, and 16 months and confirmed drug\u2010eluting stent patency in each case. <jats:styled-content>Conclusions:<\/jats:styled-content> The use of below\u2010knee drug\u2010eluting stents is feasible and appears to be safe in our small series of complex infrapopliteal lesions causing chronic limb ischemia. The occurrence of a single case of stent thrombosis warrants continued observation in this cohort. Prospective clinical trials will be necessary to confirm the benefits and justify the costs of this strategy for treating patients with infrapopliteal culprit lesions and chronic limb ischemia. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.21367","type":"journal-article","created":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T19:14:45Z","timestamp":1198178085000},"page":"108-111","source":"Crossref","is-referenced-by-count":29,"title":["Infrapopliteal drug\u2010eluting stents for chronic limb ischemia"],"prefix":"10.1002","volume":"71","author":[{"given":"A.G.","family":"Grant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Ramee,","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.11.041"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032441"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/97382129"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4201.097943"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02133405"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.2.8327682"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02733924"},{"issue":"2","key":"e_1_2_7_10_2","first-page":"I86","article-title":"Clinical and anatomical considerations for nonoperative therapy in tibial disease and the results of angioplasty","volume":"83","author":"Schwarten DE","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61332-3"},{"key":"e_1_2_7_12_2","first-page":"30","article-title":"[Percutaneous balloon dilatation of isolated lesions of the calf arteries in critical ischemia of the leg]","volume":"23","author":"Wack C","year":"1994","journal-title":"Vasa"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.037"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20893"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20255"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1583\/05-1620MR.1"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.009"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02597-4"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310802"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310801"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.065"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0455.2000.041001073.x"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820925"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(98)70033-3"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.21367","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.21367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:43:32Z","timestamp":1697431412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.21367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,20]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/ccd.21367"],"URL":"https:\/\/doi.org\/10.1002\/ccd.21367","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,20]]}}}