{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T16:18:27Z","timestamp":1774455507982,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Sirolimus\u2010eluting stents have been increasingly used for treatment of restenosis after implantation of bare metal stents (BMSs) or drug\u2010eluting stents (DESs), but little is known regarding their long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We compared long\u2010term clinical outcomes in 295 patients treated with sirolimus\u2010eluting stents for post\u2010BMS (<jats:italic>n<\/jats:italic> = 224) vs. post\u2010DES (<jats:italic>n<\/jats:italic> = 71) restenosis. All follow\u2010ups were at least 12 months, and the primary endpoint was major adverse cardiac events (MACE), defined as cardiac death, nonfatal myocardial infarction (MI) or target lesion revascularization (TLR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Baseline characteristics were similar between the two groups, except that mean lesion length (28.0 \u00b1 16.2 vs. 19.5 \u00b1 13.6, <jats:italic>P<\/jats:italic> &lt; 0.01) and mean stented length (35.4 \u00b1 19.2 vs. 25.7 \u00b1 14.7, <jats:italic>P<\/jats:italic> &lt; 0.01) were significantly longer in the post\u2010BMS group. Major in\u2010hospital complications occurred in 2 patients. During a mean follow\u2010up of 31.3 \u00b1 11.1 months, there were 9 deaths (4 cardiac, 5 noncardiac), 3 nonfatal MIs, and 25 TLRs. Late stent thrombosis was documented in 2 patients (1 in each group). There were no between group differences in cardiac or total deaths, but there were trends toward less frequent cardiac death\/MI or TLR in the post\u2010BMS group. The cumulative probability of MACE\u2010free survival was significantly better for the post\u2010BMS group (95.0% \u00b1 1.5% vs. 87.3% \u00b1 4.0% at 1 year; 93.0% \u00b1 1.7% vs. 81.0% \u00b1 5.2% at 2 years; Log Rank <jats:italic>P<\/jats:italic> = 0.016). In multivariate analysis, post\u2010DES restenosis was the only significant predictor of MACE (OR 3.29, 95%CI 1.13\u20139.61, <jats:italic>P<\/jats:italic> = 0.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Sirolimus\u2010eluting stents were effective for treatment of in\u2010stent restenosis, but post\u2010DES restenosis was associated with poorer outcomes than post\u2010BMS restenosis. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.21399","type":"journal-article","created":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T19:46:25Z","timestamp":1204400785000},"page":"594-598","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term clinical outcomes after sirolimus\u2010eluting stent implantation for treatment of restenosis within bare\u2010metal versus drug\u2010eluting stents"],"prefix":"10.1002","volume":"71","author":[{"given":"Cheol","family":"Whan Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk\u2010Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Hak","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong\u2010Ki","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Wook","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044372"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.025536"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1215"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.165"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.18.1872"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00202-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.11.1253"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.11.1264"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.12.009"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130173.63105.4E"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.07.027"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.06.027"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21106"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.049"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.21399","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.21399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:16:03Z","timestamp":1697501763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.21399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/ccd.21399"],"URL":"https:\/\/doi.org\/10.1002\/ccd.21399","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}