{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:15:19Z","timestamp":1776377719641,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T00:00:00Z","timestamp":1206057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives and Background:<\/jats:title><jats:p>Percutaneous aortic valve replacement is a new less\u2010invasive alternative for high\u2010risk surgical candidates with aortic stenosis. However, the clinical experience is still limited, and the currently available \u2018first\u2010generation devices\u2019 revealed technical shortcomings, such as lack of repositionability and presence of paravalvular leakages. We report the first\u2010in\u2010man experience with the new self\u2010expanding Lotus\u2122 Valve prosthesis composed of a nitinol frame with implemented bovine pericardial leaflets which is designed to address these issues, being repositionable and covered by a flexible membrane to seal paravalvular gaps. We implanted this prosthesis in a 93\u2010year old patient presenting with severe symptomatic aortic stenosis (valve area: 0.6 cm<jats:sup>2<\/jats:sup>). Surgical valve replacement had been declined due to comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results:<\/jats:title><jats:p>We used a retrograde approach for insertion of the 21\u2010French Lotus catheter loaded with the valve prosthesis via surgical cut\u2010down to the external iliac artery. Positioning of the valve was guided by transesophageal echo and supra\u2010aortic angiograms. The prosthesis was successfully inserted and deployed within the calcified native valve. Echocardiography immediately after device deployment showed a significant reduction of the transaortic mean pressure gradient (32 to 9 mmHg; final valve area 1.7 cm<jats:sup>2<\/jats:sup>) without evidence of residual aortic regurgitation. The postprocedural clinical status improved from NYHA\u2010IV to NYHA\u2010II. These results remained unchanged up to the 3 month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Successful percutaneous aortic valve replacement can be performed using the new self\u2010expanding and repositionable Lotus valve for treatment of high\u2010risk patients with aortic valve stenosis. Further studies are mandatory to assess device safety and efficacy in larger patient populations. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.21470","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T20:17:07Z","timestamp":1206130627000},"page":"579-584","source":"Crossref","is-referenced-by-count":51,"title":["Percutaneous implantation of the first repositionable aortic valve prosthesis in a patient with severe aortic stenosis"],"prefix":"10.1002","volume":"71","author":[{"given":"Lutz","family":"Buellesfeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Gerckens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Grube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707033370107"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp010846"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.4.1109"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2006.05.021","article-title":"ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (writing Committee to Revise the 1998 guidelines for the management of patients with valvular heart disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons","volume":"48","author":"Bonow RO","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90627-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.5.1105"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00201-X"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi471"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01670-2"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047200.36165.B8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20544"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.632927"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.026"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134961.36773.D6"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.01.049"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.582882"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.698258"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.639450"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.047"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21282"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21300"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00146-3"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.055"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.8.901"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.21470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.21470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:16:49Z","timestamp":1697501809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.21470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,21]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/ccd.21470"],"URL":"https:\/\/doi.org\/10.1002\/ccd.21470","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,21]]}}}