{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:21:01Z","timestamp":1789593661168,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T00:00:00Z","timestamp":1208217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives:<\/jats:styled-content> The purpose of this study was to assess the long\u2010term limb preservation and\/or healing of ulcers in patients with critical limb ischemia (CLI) and severe infrapopliteal atherosclerotic disease treated with drug eluting stents (DES). <jats:styled-content>Background:<\/jats:styled-content> Percutaneous revascularization has become an effective treatment for CLI in patients with infrapopliteal atherosclerotic disease. Recent reports using DES in patients with CLI have documented excellent short\u2010term infrapopliteal vessel patency. Higher primary patency rates in infrapopliteal vessels treated with DES could translate into better long\u2010term clinical outcomes and improved limb salvage rates. <jats:styled-content>Methods:<\/jats:styled-content> Twenty\u2010four consecutive patients with CLI (defined as rest pain, nonhealing ulcers, or gangrene) because of severe infrapopliteal disease were treated with DES from August 2004 to June 2006. <jats:styled-content>Results:<\/jats:styled-content> Procedural success was achieved in 96% (27\/28) of targeted lesions. There were no procedure\u2010related deaths, acute vessel thrombosis events, or need for urgent surgical intervention. There was one case of distal embolization. Clinical follow up, ranging 8\u201334 months, is available for 100% of patients of which 83% (20\/24) achieved limb preservation and healing. Angiographic and\/or sonographic follow up, ranging 6\u201334 months, is available in 79% (19\/24) of patients of which 95% (18\/19) had patent target vessels. <jats:styled-content>Conclusions:<\/jats:styled-content> DES is a safe and effective long\u2010term option for CLI due to severe infrapopliteal arterial disease. Long\u2010term vascular patency led to a high rate of limb preservation and low amputation rate. A multicenter trial should further elucidate the role of DES in the treatment of CLI. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.21557","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T22:23:54Z","timestamp":1208298234000},"page":"112-115","source":"Crossref","is-referenced-by-count":31,"title":["Drug eluting stents for below the knee lesions in patients with critical limb ischemia"],"prefix":"10.1002","volume":"72","author":[{"given":"Oscar R.","family":"Rosales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiny","family":"Mathewkutty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Gnaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","article-title":"Second European consensus document on chronic critical leg ischemia","volume":"6","author":"European Chronic Leg Ischemia Consensus Group","year":"1992","journal-title":"Eur J Vasc Surg"},{"key":"e_1_2_6_3_2","first-page":"1","article-title":"Management of peripheral arterial disease (PAD). 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