{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T22:44:56Z","timestamp":1759099496321},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T00:00:00Z","timestamp":1216857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prosthetic valve thrombosis is a dangerous and unfortunately not uncommon medical situation, often seen as a medical emergency. Patients with previously unseen and more confounding medical problems are presenting, making the decision regarding therapeutic options even more complicated. In this case report, we describe a complicated patient with mechanical mitral valve prosthesis placed secondary to rheumatic heart disease, with multiple co\u2010morbidities including severe left ventricular dysfunction, permanent artrial fibrillation, left femoral deep vein thrombosis, and non\u2010sustained ventricular tachycardia, who presented with acute valve thrombosis. The patient' history of hemorrhagic stroke and multiple acute ischemic strokes represented an absolute contraindication to more conventional forms of therapy such as intravenous systemic thrombolytics. In the following case report, we present an unprecedented approach to prosthetic valve thrombosis in this seemingly no\u2010option patient. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.21585","type":"journal-article","created":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T05:31:28Z","timestamp":1216963888000},"page":"151-155","source":"Crossref","is-referenced-by-count":5,"title":["Localized left atrial administration of tPA for the treatment of mechanical mitral valve thrombosis"],"prefix":"10.1002","volume":"72","author":[{"given":"Sapna","family":"Desai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford","family":"Kavinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70055-7"},{"key":"e_1_2_5_3_2","first-page":"8","article-title":"Mechanical cardiac valve thrombosis","volume":"86","author":"Roudaut R","year":"1992","journal-title":"Is fibrinolysis justified? Circulation"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(96)01133-5"},{"key":"e_1_2_5_5_2","first-page":"291","article-title":"Unexpected findings concerning thromboembolic complications and anticoagulation after complete 10 year follow up of patients with St. Jude medical prostheses","volume":"2","author":"Horstkotte D","year":"1993","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_5_6_2","first-page":"114","article-title":"Intracardiac thrombosis: Patient\u2010related and device\u2010related factors","volume":"4","author":"Horstkotte D","year":"1995","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2004.06.003"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000099531.29957.94"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20557"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608083350607"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02394-9"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.amjcard.2005.07.112","article-title":"Feasability and diagnostic accuracy of quantitative assessment of mechanical prostheses leaflet motion by transthoracic and transesophageal echocardiography in suspected prosthetic valve dysfunction","volume":"97","author":"Muratori M","year":"2006","journal-title":"Am J Cardiol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90742-U"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.21585","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.21585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:49:27Z","timestamp":1700077767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.21585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,24]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1002\/ccd.21585"],"URL":"https:\/\/doi.org\/10.1002\/ccd.21585","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,24]]}}}