{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:17:00Z","timestamp":1791217020995,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T00:00:00Z","timestamp":1207872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Background:<\/jats:styled-content> Permanent polymers used in current drug\u2010eluting stents (DES) can trigger chronic inflammation and hypersensitivity reactions, which may contribute to the increased risk of late thrombosis and rebound restenosis. Therefore, optimal polymer selection and the use of completely absorbable but biocompatible polymers are expected to minimize these risks. <jats:styled-content>Objectives:<\/jats:styled-content> We sought to evaluate a novel, potentially innately anti\u2010inflammatory, bioabsorbable salicylate\u2010based polymer as a DES coating, in a clinically relevant animal model. <jats:styled-content>Methods:<\/jats:styled-content> Four types of stents were implanted in pig coronary arteries using QCA to optimize stent apposition: bare metal stents (BMS); salicylic acid\/adipic acid bioabsorbable polymer\u2010only coated metal stents (SA\/AA); biostable polymeric sirolimus\u2010eluting stents (Cypher\u2122); and metal stents coated with salicylic acid\/adipic acid bioabsorbable polymer containing sirolimus (SA\/AA + S). The dose density of sirolimus was 8.3 \u03bcg\/mm of stent length (similar to Cypher\u2122) with in vitro studies demonstrating elution over 30 days and complete polymer degradation in 37 days. Animals underwent angiographic restudy and were terminated at 1 month for complete histopathologic and histomorphometric analyses. <jats:styled-content>Results:<\/jats:styled-content> Both SA\/AA + S and Cypher\u2122 stents had significantly lower angiographic % stenosis when compared with BMS and SA\/AA polymer\u2010only groups (6 \u00b1 4% and 5 \u00b1 4% vs. 15 \u00b1 7% and 16 \u00b1 5%, respectively, <jats:italic>P<\/jats:italic> &lt; 0.001). Intimal thickness was lower for SA\/AA + S and Cypher\u2122 than for BMS (0.14 \u00b1 0.06 and 0.13 \u00b1 0.04 mm vs. 0.23 \u00b1 0.05 mm, respectively, <jats:italic>P<\/jats:italic> &lt; 0.001). Histologic % area stenosis was also lower for SA\/AA + S and Cypher\u2122 when compared with BMS (22 \u00b1 7% and 23 \u00b1 6% vs. 33 \u00b1 5%, respectively, <jats:italic>P<\/jats:italic> &lt; 0.001). There was a strong trend toward reduced inflammatory response in the SA\/AA and SA\/AA + S when compared with BMS and Cypher\u2122 groups (<jats:italic>P<\/jats:italic> = 0.072). <jats:styled-content>Conclusions:<\/jats:styled-content> This study shows favorable vascular compatibility and efficacy for a novel bioabsorbable salicylate\u2010based polymer as a DES coating, and supports further research and development of this unique class of polymer materials for applications in cardiovascular devices. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.21607","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T17:16:26Z","timestamp":1207934186000},"page":"186-194","source":"Crossref","is-referenced-by-count":50,"title":["Novel bioabsorbable salicylate\u2010based polymer as a drug\u2010eluting stent 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