{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:22:10Z","timestamp":1761578530719,"version":"3.35.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,6,16]],"date-time":"2008-06-16T00:00:00Z","timestamp":1213574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>To investigate the long\u2010term prognostic implications of complete versus incomplete revascularization in multivessel coronary artery disease (MVD) patients undergoing percutaneous coronary intervention (PCI) with drug\u2010eluting stent (DES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background:<\/jats:title><jats:p>Coronary artery bypass grafting (CABG) in patients with MVD provides better outcomes when complete revascularization is achieved. There is a paucity of data on the outcomes of complete versus incomplete revascularization of MVD patients undergoing PCI, and currently there is no data available with DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Patients with MVD undergoing PCI with DES (sirolimus\u2010 or paclitaxel\u2010eluting stent) were included. Comparisons of long\u2010term outcomes between completely versus incompletely revascularized patients were made. The primary outcome measure was the composite of cardiac death, nonfatal myocardial infarction (MI), or any revascularization. Secondary endpoints were the components of the composite endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 508 patients were considered for this analysis: 212 (41.7%) and 296 (58.3%) had complete and incomplete revascularization, respectively. The median follow\u2010up was 27.0 (interquartile range: 23.0\u201337.1) months. After adjusting for baseline characteristics, the hazard ratio (HR, 95% confidence interval) for complete revascularization was 0.43 (0.29\u20130.63,<jats:italic>P<\/jats:italic>&lt; 0.0001) for the primary composite endpoint. Complete revascularization was associated with better outcomes for components of the composite endpoint: 0.37 (0.15\u20130.92,<jats:italic>P<\/jats:italic>= 0.03) for cardiac death, 0.34 (0.16\u20130.75<jats:italic>P<\/jats:italic>= 0.008) for the composite of cardiac death or MI and 0.45 (0.29\u20130.69,<jats:italic>P<\/jats:italic>= 0.0003) for any repeat revascularization. This association was confirmed in a propensity\u2010matched population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Complete revascularization with DES of MVD patients is associated with lower rates of long\u2010term adverse events. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.21666","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T17:29:51Z","timestamp":1222363791000},"page":"448-456","source":"Crossref","is-referenced-by-count":39,"title":["Complete versus incomplete revascularization in patients with multivessel disease undergoing percutaneous coronary intervention with drug\u2010eluting stents"],"prefix":"10.1002","volume":"72","author":[{"given":"Corrado","family":"Tamburino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piera","family":"Capranzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"La Manna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Barbagallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Tagliareni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mangiafico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo R.","family":"Galassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore A.","family":"Bass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-5223(19)39327-4","article-title":"Long\u2010term results following coronary bypass operation: Importance of preoperative factors and complete revascularization","volume":"82","author":"Buda AJ","year":"1981","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80003-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.2.446"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.12.034"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01806-X"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01785-5"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.9.910"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1997.0574"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.10.037"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.612267"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.03.026"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.082"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.081"},{"key":"e_1_2_6_15_2","first-page":"147","article-title":"Arterial Revascularisation Therapies Study Part II., Sirolimus\u2010eluting stents for the treatment of patients with multivessel de novo coronary artery lesions","volume":"1","author":"Serruys PW","year":"2005","journal-title":"Eur Intervention"},{"key":"e_1_2_6_16_2","first-page":"53","article-title":"Revascularization strategies of coronary multivessel disease in the drug\u2010eluting stent era: One year follow\u2010up results of the ERACI\u2010III trial","volume":"2","author":"Rodriguez AE","year":"2006","journal-title":"Eur Intervention"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104123441502"},{"key":"e_1_2_6_18_2","unstructured":"R Development Core Team. 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