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We describe an unusual case of rapid\u2010onset HIT resulting in massive\u2010bilateral pulmonary emboli in a 70 year\u2010old man who developed chest pain during elective percutaneous coronary intervention (PCI). The diagnosis was made the following day after persistent chest pain and laboratory work demonstrating a new thrombocytopenia, a mildly elevated troponin, and positive DIC panel led to confirmatory imaging tests. HIT\u2010related thrombosis should be considered in the differential diagnosis of chest pain in patients undergoing PCI. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.21732","type":"journal-article","created":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T19:38:40Z","timestamp":1221593920000},"page":"819-822","source":"Crossref","is-referenced-by-count":1,"title":["Heparin\u2010induced thrombocytopenia (HIT) causing pulmonary emboli during coronary intervention"],"prefix":"10.1002","volume":"72","author":[{"given":"Ronny S.","family":"Jiji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Michaels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,16]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104263441704"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8191.2003.02036.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1160\/TH04-12-0825","article-title":"Clinical features of heparin\u2010induced thrombocytopenia including risk factors for thrombosis: A retrospective analysis of 408 patients","volume":"94","author":"Kohlmann T","year":"2005","journal-title":"Thromb Haemost"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00258-6"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-012450"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00124-2"},{"key":"e_1_2_4_8_2","first-page":"731","article-title":"Laboratory diagnosis of heparin\u2010induced thrombocytopenia and monitoring of alternative anticoagulants","volume":"5","author":"Leo A","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000225071.53902.e9"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2005.04070.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10536"},{"issue":"1","key":"e_1_2_4_12_2","first-page":"3","article-title":"Failure of current strategies in the prevention of thrombosis in patients with heparin\u2010induced thrombocytopenia: A clinician's persepective","volume":"25","author":"Wallis DE","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3_suppl.311S"},{"key":"e_1_2_4_14_2","first-page":"28","article-title":"Plasmapheresis in the management of heparin\u2010induced thrombocytopenia","volume":"36","author":"Robinson JA","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(97)00254-5"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1309\/BMW4M8NQBV0TKFRX"},{"issue":"1","key":"e_1_2_4_17_2","first-page":"77","article-title":"Clinical experience with combined treatment of thrombin inhibitors and GPIIb\/IIIa inhibitors in patients with HIT","volume":"25","author":"Walenga JM","year":"1999","journal-title":"Semin Thomb Hemost"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.21732","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.21732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:10:16Z","timestamp":1697436616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.21732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,16]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,11,15]]}},"alternative-id":["10.1002\/ccd.21732"],"URL":"https:\/\/doi.org\/10.1002\/ccd.21732","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,16]]}}}