{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:34:46Z","timestamp":1761561286793},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T00:00:00Z","timestamp":1225065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives:<\/jats:styled-content> Chronic implants of the PS<jats:sup>3<\/jats:sup>\u2122 system were conducted in an ovine model to assess durability and safety at up to 1 year follow\u2010up. <jats:styled-content>Background:<\/jats:styled-content> The long\u2010term durability and safety of emerging percutaneous devices for functional mitral regurgitation remain largely unknown. <jats:styled-content>Methods:<\/jats:styled-content> The PS<jats:sup>3<\/jats:sup> system (consisting of interatrial septal and great cardiac vein devices connected by an adjustable suture bridge) was placed in eight healthy adult sheep. The mitral annular septal\u2010lateral dimension in systole (SLS) was acutely reduced by 15\u201320%. Animals were sacrificed at up to 12 months postimplant and characterized by intracardiac echocardiography, cardiac computed tomography (CT), and histopathology. <jats:italic>In vivo<\/jats:italic> forces exerted on the PS<jats:sup>3<\/jats:sup> bridge were measured by means of a novel load cell catheter. <jats:styled-content>Results:<\/jats:styled-content> At 3, 6, and 12 months after implantation, intracardiac echocardiographic and CT showed the PS<jats:sup>3<\/jats:sup> systems to be intact without erosion and with overall sustained reductions in the SLS. Histopathologic assessment revealed each component correctly deployed in its respective target site without evidence of erosion, thrombus, or device fracture. The SLS was 26.5 \u00b1 1.7 mm preimplant, 22.0 \u00b1 1.4 mm post\u2010PS<jats:sup>3<\/jats:sup> (17.0% reduction), and 22.0 \u00b1 2.1 mm at latest follow\u2010up. Mean forces exerted on the bridge <jats:italic>in vivo<\/jats:italic> ranged from 1.16 N to 1.87 N. <jats:styled-content>Conclusions:<\/jats:styled-content> The PS<jats:sup>3<\/jats:sup> System demonstrated excellent biocompatibility without evidence of erosion, thrombosis, or perforation at up to one\u2010year follow\u2010up in this chronic healthy ovine model. Forces exerted in the PS<jats:sup>3<\/jats:sup> system were relatively modest and should contribute to the durability of the device. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.21818","type":"journal-article","created":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T17:34:38Z","timestamp":1225128878000},"page":"540-548","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term safety and durability of percutaneous septal sinus shortening (The PS<sup>3<\/sup> System\u2122) in an ovine model"],"prefix":"10.1002","volume":"73","author":[{"given":"Jason H.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Rahdert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary R.","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor F.","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fermin O.","family":"Tio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginald I.","family":"Low","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146904.13677.E4"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000096051.23734.28"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10662"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.085"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.601518"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.591602"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20810"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70282-X"},{"key":"e_1_2_5_10_2","first-page":"536","article-title":"Mitral valve reconstruction and replacement for ischemic mitral insufficiency: Seven years' follow up","volume":"8","author":"Hausmann H","year":"1999","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.1669"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.7.783"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.026"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20211"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21070"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-5223(19)39144-5","article-title":"Cardiac valve surgery\u2013the \u201cFrench correction.\u201d","volume":"86","author":"Carpentier A","year":"1983","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90455-V"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90865-A"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1999"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.3.498"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.043"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.073"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc37t1.094913"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.122296"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.609883"},{"issue":"8","key":"e_1_2_5_26_2","first-page":"57L","article-title":"Significant Reverse Remodeling of the Left Ventricle One Year After Percutaneous Mitral Repair with the MitraClip Device. 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