{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T19:52:24Z","timestamp":1713815544260},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T00:00:00Z","timestamp":1231372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>To evaluate the feasibility of a new 0.014\u2033 CiTop\u2122 guidewire to cross total occlusions within normal and diseased blood vessels; proof of concept. Background: Despite recent advances, chronic arterial occlusions remain the main obstacle of coronary and peripheral interventions. Methods: The OVALUM CiTop\u2122 0.014\u2033 guidewire is an over\u2010the\u2010wire catheter designed to penetrate through chronic total occlusions (CTO) and allow for further PCI interventions. The CiTop\u2122 guidewire was tested in normal peripheral and coronary arteries of swine (<jats:italic>n<\/jats:italic> = 7) and in totally occluded arterial lesions within human amputations (<jats:italic>n<\/jats:italic> = 10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The CiTop\u2122 0.014\u2033 guidewire was operated successfully in seven peripheral blood vessels and 12 coronary arteries without angiographic or histological evidence of damage to the arterial wall. The CiTop\u2122 crossed 9 of the 10 occluded segments within the human amputation with no angiographic or histological evidence of arterial damage (90% success rate). Average time to cross the occlusion was 4.6 \u00b1 5.6 min. In one artery (10%), angiographic evidence of perforation was noted and there was histological evidence for arterial wall damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Our data show that the new 0.014\u2033 CiTop\u2122 guidewire can be well operated within normal peripheral and coronary arteries of swine, and with minimal complications within totally occluded blood vessels from human amputations while effectively penetrating and crossing total arterial occlusions. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.21978","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T20:08:19Z","timestamp":1231445299000},"page":"278-285","source":"Crossref","is-referenced-by-count":2,"title":["Crossing chronic total occlusions with a new 0.014\u2033 CiTop guidewire: Proof of concept"],"prefix":"10.1002","volume":"74","author":[{"given":"Mickey","family":"Scheinowitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Amrami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Oppenhaim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Engelberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oren","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Belenky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Siev\u2010Ner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"342","volume-title":"National Hospital Discharge Survey: Advance Data From Vital and Health Statistics","author":"DeFrances CJ","year":"2002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.481283"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.12.040"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/17482940600885469"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-007-0519-7"},{"key":"e_1_2_6_7_2","first-page":"85","article-title":"High\u2010frequency mechanical vibration to recanalize chronic total occlusions after failure to cross with conventional guidewires","volume":"18","author":"Grube E","year":"2006","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_8_2","first-page":"489","article-title":"The latest wire technique for chronic total occlusion","volume":"6","author":"Ochiai M","year":"2005","journal-title":"Ital Heart J"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20979"},{"key":"e_1_2_6_10_2","first-page":"E263","article-title":"Contact wire technique: a possible strategy for parallel wire techniques","volume":"19","author":"Horisaki T","year":"2007","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70293-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21396"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20716"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20754"},{"key":"e_1_2_6_15_2","first-page":"230","article-title":"Combined angioplasty with the Kensey catheter and balloon angioplasty in occlusive arterial disease. 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