{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:20:38Z","timestamp":1761862838166},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Percutaneous closure of the left atrial appendage (LAA) is a novel alternative for the treatment of patients with atrial fibrillation (AF) and with a high risk of stroke who are not eligible for long\u2010term anticoagulation therapy. The aim of this study was to asses the safety, feasibility, and long\u2010term efficacy of this procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>From July 2004 to June 2007, 20 patients (13 male, mean age 69 \u00b1 8 years) with non\u2013valvular AF (NV\u2010AF) underwent LAA percutaneous closure using the PLAATO\u2122 system, implanted through a transeptal access. All patients had contraindications to anticoagulant therapy and were at high risk for cardioembolic stroke (mean CHADS<jats:sub>2<\/jats:sub> score 3 \u00b1 1.2). A trans\u2010thoracic echocardiogram was performed at 1, 3, and every 6 months after the procedure, whereas a trans\u2010oesophageal echocardiogram (TOE) was scheduled at 6 months. After 24 months, a phone interview was obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>All procedures were successfully performed in 18 patients. In two patients, LAA closure was not feasible for the presence of a multilobed LAA. Two patients underwent percutaneous closure of patent foramen ovale in the same session. In one patient, the procedure was complicated by cardiac perforation with pericardial effusion, treated with pericardiocentesis. At a mean follow up of 40 \u00b1 10 months, no embolic events occurred. One patient died, after 36 months, for gastric cancer. TOE examination showed the complete exclusion of the LAA in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Percutaneous closure of LAA is safe and efficacious to prevent stroke in patients with NV\u2010AF at high risk for cardioembolic events, with contraindications to anticoagulant therapy. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.22099","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T23:26:32Z","timestamp":1240874792000},"page":"217-222","source":"Crossref","is-referenced-by-count":18,"title":["Percutaneous closure of left atrial appendage to prevent embolic events in high\u2010risk patients with chronic atrial fibrillation"],"prefix":"10.1002","volume":"74","author":[{"given":"Gian 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