{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:20:40Z","timestamp":1761862840224},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>The surgical creation of an aortopulmonary shunt is an important tool in the therapy of complex congenital heart defects. We report on a transcatheter approach to establish an aortopulmonary shunt in piglets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material, Methods and Results:<\/jats:title><jats:p>In 10 piglets with a median body weight of 10.5 kg (8\u201312 kg), a central aortopulmonary shunt was created by radiofrequency perforation from the aorta to the pulmonary trunk, followed by stent implantation. The procedures were performed via the femoral vessels through 5F sheaths under biplane fluoroscopy guidance. A total of six bare metal coronary stents and five polytetrafluoroethylene\u2010covered coronary stents of 3\u20134 mm diameter were deployed. Four animals were sacrificed immediately after intervention; six pigs were reevaluated 4\u20135 weeks later for stent patency and measurement of shunt volume. The procedure was successful in all pigs. Median shunt volume was Qp:Qs = 2.4:1. At re\u2010evaluation median body weight had increased to 18 kg (15.5\u201327.5 kg) <jats:italic>P<\/jats:italic> &lt; 0.028. Four of six stents were completely obstructed due to tissue ingrowth in the bare metal stents (two cases) and thrombus formation in the covered stents (two cases). A third bare metal stent had a residual lumen, and a third covered stent was fully open without any thrombus formation or tissue ingrowth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Transcatheter creation of an aortopulmonary shunt by radiofrequency perforation and stent implantation is feasible. The use of appropriate covered stents and an effective anticoagulatory regimen seem to be crucial to keep the shunts open. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.22150","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T20:27:01Z","timestamp":1242419221000},"page":"563-569","source":"Crossref","is-referenced-by-count":10,"title":["Transcatheter creation of an aortopulmonary shunt in an animal model"],"prefix":"10.1002","volume":"75","author":[{"given":"Titus Mbah","family":"Sabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Sigler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyhan Sayadpour","family":"Zanjani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislav","family":"Ovroutski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjoern","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Miera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Nagdyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titus","family":"Kuehne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ewert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,11]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"2123","article-title":"Landmark article May 19, 1945: The surgical treatment of malformations of the heart in which there is pulmonary stenosis or pulmonary atresia","volume":"251","author":"Blalock A","year":"1984","journal-title":"JAMA"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/08941930500232379"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)42698-6"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)39351-1"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70113-2"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016925309136722"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1258\/la.2007.007027"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/92.5.1112"},{"key":"e_1_2_7_10_2","first-page":"406","article-title":"The transjugular intrahepatic portosystemic stent\u2010shunt. 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