{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:17:00Z","timestamp":1791217020802,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T00:00:00Z","timestamp":1244505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives:<\/jats:styled-content> We tested two novel drug\u2010eluting stents (DES), covered with a biodegradable\u2010polymer carrier and releasing paclitaxel or sirolimus, which were compared against a bare metal stent (primary objective). The DES differed by the drug, but were identical otherwise, allowing to compare the anti\u2010restenosis effects of sirolimus versus paclitaxel (secondary objective). <jats:styled-content>Background:<\/jats:styled-content> The efficacy of novel DES with biodegradable polymers should be tested in the context of randomized trials, even when using drugs known to be effective, such as sirolimus and paclitaxel. <jats:styled-content>Methods:<\/jats:styled-content> Overall, 274 patients with de novo coronary lesions in native vessels scheduled for stent implantation were randomly assigned (2:2:1 ratio) for the paclitaxel (<jats:italic>n<\/jats:italic> = 111), sirolimus (<jats:italic>n<\/jats:italic> = 106), or bare metal stent (<jats:italic>n<\/jats:italic> = 57) groups. Angiographic follow\u2010up was obtained at 9 months and major cardiac adverse events up to 12 months. <jats:styled-content>Results:<\/jats:styled-content> Both paclitaxel and sirolimus stents reduced the 9\u2010month in\u2010stent late loss (0.54\u20130.44 mm, 0.32\u20130.43 mm, vs. 0.90\u20130.45 mm respectively), and 1\u2010year risk of target vessel revascularization and combined major adverse cardiac events (<jats:italic>P<\/jats:italic> &lt; 0.05 for both, in all comparisons), compared with controls. Sirolimus stents had lower late loss than paclitaxel stents (<jats:italic>P<\/jats:italic> &lt; 0.01), but similar 1\u2010year clinical outcomes. There were no differences in the risk of death, infarction, or stent thrombosis among the study groups. <jats:styled-content>Conclusion:<\/jats:styled-content> Both novel DES were effective in reducing neointimal hyperplasia and 1\u2010year re\u2010intervention, compared to bare metal stents. Our findings also suggest that sirolimus is more effective than paclitaxel in reducing angiographic neointima, although this effect was not associated with better clinical outcomes.\u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22166","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T19:44:33Z","timestamp":1244576673000},"page":"665-673","source":"Crossref","is-referenced-by-count":26,"title":["Randomized evaluation of two drug\u2010eluting stents with identical metallic platform and biodegradable polymer but different agents (paclitaxel or sirolimus) compared against bare stents: 1\u2010Year results of the PAINT trial"],"prefix":"10.1002","volume":"74","author":[{"given":"Pedro A.","family":"Lemos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Moulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Perin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmilla A.R.R.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Airton","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter C.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio A.G.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo R.A.","family":"Caramori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar R.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio R.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Fabio S.","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Expedito E.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eul\u00f3gio E.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,7]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147275.50550.68"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109138.84579.FA"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067193"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066633"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067731"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61244-1"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.062"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051175"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044372"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67221-2"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi721"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.8.895"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20755"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.666396"},{"issue":"15","key":"e_1_2_8_16_2","first-page":"e11","article-title":"Drug\u2010eluting stents for the treatment of bifurcation lesions: a randomized comparison between paclitaxel and sirolimus stents","volume":"153","author":"Pan M","year":"2007","journal-title":"Am Heart J"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.042"},{"key":"e_1_2_8_18_2","article-title":"Rationale and design for the PAINT randomized trial","author":"Lemos PA","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000100560.46946.EA"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.666826"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-7180-7"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14462-5"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1215"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.02.053"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm425"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.084"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.22166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.22166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:48:26Z","timestamp":1697467706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.22166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,7]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/ccd.22166"],"URL":"https:\/\/doi.org\/10.1002\/ccd.22166","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,7]]}}}