{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:03:04Z","timestamp":1791925384584,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T00:00:00Z","timestamp":1244505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2009,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold><jats:styled-content>Objectives<\/jats:styled-content><\/jats:bold>: In this study, we evaluated the incidence of new onset atrial fibrillation (symptomatic or detected by routine ECG) after patent foramen ovale (PFO\u2010) closure. <jats:bold><jats:styled-content>Background<\/jats:styled-content><\/jats:bold>: Although atrial fibrillation is known to occur in some patients following patent foramen ovale closure, the incidence and the risk associated with each device is not well known. <jats:bold><jats:styled-content>Methods<\/jats:styled-content><\/jats:bold>: We evaluated 1,349 consecutive patients who underwent PFO closure with an approved device and examined the incidence and risk factors associated with the development of atrial fibrillation. The patients had a mean age of 50 years and underwent PFO closure for cerebrovascular accident in 696 (51.6%), transient ischemic attack in 610 (45.2%), paradoxical embolism in 22 (1.6%), decompression sickness in 13 (0.9%), and other reasons including migraine headaches in 6 (0.4%) of cases. <jats:bold><jats:styled-content>Results<\/jats:styled-content><\/jats:bold>: Over a mean follow\u2010up period of 38.1 \u00b1 28 months, 53 (3.9%) patients developed new onset atrial fibrillation, which is higher compared with an age\u2010matched population. Of these, 33 (62.3%) patients developed atrial fibrillation within 4 weeks and 8 (15%) within 6 months following PFO closure (totally 77% from 0 to 6 months). The event consisted of a single paroxysm lasting less than 48 hr in 23 patients, resolving either spontaneously or with cardioversion. 40 (75.5%) patients were symptomatic at the time of diagnosis. Thirty (56.6%) patients developed chronic atrial fibrillation. On multivariate analysis, advanced age and use of the STARFlex device predicted atrial fibrillation. <jats:bold><jats:styled-content>Conclusions<\/jats:styled-content><\/jats:bold>: The number of patients in whom atrial fibrillation was detected was relatively low. It is often a self\u2010limited complication of PFO closure that may occur more frequently in elderly patients and those treated with the STARFlex device. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22172","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T19:45:25Z","timestamp":1244576725000},"page":"889-895","source":"Crossref","is-referenced-by-count":83,"title":["New onset atrial fibrillation after patent foramen ovale closure"],"prefix":"10.1002","volume":"74","author":[{"given":"Stephan","family":"Staubach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wibke","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Wawra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Wunderlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2001.tb00740.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2001.tb00745.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.12.054"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027819.19722.EE"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.10.021"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017498.88393.44"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000019069.32964.0E"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-004-0035-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2006.00154.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20722"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2005.04050.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2005.00948.x"},{"key":"e_1_2_5_14_2","first-page":"32","article-title":"Current management of patients with patent foramen ovale and cryptogenic stroke: Our experience and review of the literature","volume":"103","author":"Bailey CE","year":"2004","journal-title":"WMJ"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20108"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8183.2003.08002.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2002.003111"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951100008210"},{"key":"e_1_2_5_19_2","first-page":"365","article-title":"Frequency of atrial tachyarrhythmias following transcatheter closure of patent foramen ovale","volume":"18","author":"Alaeddini J","year":"2006","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000113427"},{"key":"e_1_2_5_21_2","first-page":"854","article-title":"ACC\/AHA\/ESC 2006 guidelines for the management of patients with atrial fibrillation\u2013executive summary: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation)","volume":"48","author":"European Heart Rhythm Association; 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