{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:29:54Z","timestamp":1756992594450},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T00:00:00Z","timestamp":1247443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obstructive sleep apnea (OSA) and sleep\u2010disordered breathing have been implicated in the progression of cardiovascular disease and with increased risk of coronary artery disease, congestive heart failure, and stroke. Fractional flow reserve (FFR) is used to evaluate the physiological significance of coronary artery stenosis, and this technique is largely thought to be independent of systemic hemodynamic changes. Herein, we describe a case of OSA and sleep\u2010disordered breathing cyclically altering FFR measurements from normal to abnormal in a patient with coronary artery disease. More specifically, we show that the abnormal FFR across a coronary lesion in a patient with sleep disordered apnea improves (to a normal threshold) with the initiation of continuous positive airway pressure (CPAP). This finding may have implications for the mechanisms of cardiac dysfunction in patients with OSA. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22207","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T17:19:48Z","timestamp":1247505588000},"page":"207-213","source":"Crossref","is-referenced-by-count":7,"title":["Influence of obstructive sleep apnea and treatment with continuous positive airway pressure on fractional flow reserve measurements for coronary lesion assessment"],"prefix":"10.1002","volume":"75","author":[{"given":"Gary S.","family":"Mak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morton J.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranav M.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.11.3183"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.8.1842"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.122838"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.066837"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.055"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-3-200502010-00010"},{"key":"e_1_2_4_8_2","first-page":"136","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"15","author":"Punjabe NM","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.002"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000061757.12581.15"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000061758.05044.64"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00184-0"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00470-4"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2001008"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90552-N"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00407-6"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2004.04025.x"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.14.1906"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.7.2102003"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2007.07.006"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000217128.41284.78"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.4.1125"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.088096"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000042706.47107.7A"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07445-7"},{"key":"e_1_2_4_27_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1159\/000080635","article-title":"Sleep apnea syndrome and diastolic blood pressure elevation during exercise","volume":"71","author":"Tryfon S","year":"2004","journal-title":"Respiration"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00026608"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.22207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.22207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:02:30Z","timestamp":1697054550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.22207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,29]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/ccd.22207"],"URL":"https:\/\/doi.org\/10.1002\/ccd.22207","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,29]]}}}