{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:16:39Z","timestamp":1778818599869,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: We studied online left ventricular (LV) dynamic effects of mechanical LV unloading directly after percutaneous coronary intervention (PCI). <jats:styled-content>Background<\/jats:styled-content>: Limited clinical information is available on the direct LV dynamic consequences of LV unloading in patients undergoing high\u2010risk PCI and primary PCI for acute ST\u2010elevation myocardial infarction. <jats:styled-content>Methods<\/jats:styled-content>: The effects of the Impella LP2.5 device on LV dynamics were studied in 11 patients (elective high\u2010risk PCI, <jats:italic>n<\/jats:italic> = 6; primary PCI, <jats:italic>n<\/jats:italic> = 5). LV pressure and volume were continuously assessed by a pressure\u2010conductance catheter at 4 different support levels of the Impella, from 0 L\/min at baseline to 2.5 L\/min at maximal support. <jats:styled-content>Results<\/jats:styled-content>: The response to increased LV unloading was not different between both groups of patients. The pooled data showed no change on global and systolic LV function during increased LV unloading, while diastolic function showed improvement as indicated by an increased LV compliance in all patients. There was a decrease in end\u2010diastolic pressure from 22 \u00b1 12 to 13 \u00b1 9 mm Hg (<jats:italic>P<\/jats:italic> = 0.0001), in end\u2010diastolic elastance from 0.134 \u00b1 0.060 to 0.091 \u00b1 0.064 mm Hg\/mL (<jats:italic>P<\/jats:italic> = 0.009), and in end\u2010diastolic wall stress from 84 \u00b1 50 to 47 \u00b1 39 mm Hg (<jats:italic>P<\/jats:italic> = 0.004). <jats:styled-content>Conclusions<\/jats:styled-content>: LV unloading decreases end\u2010diastolic wall stress and improves diastolic compliance dose\u2010dependently. Our results indicate beneficial LV unloading effects of Impella during high\u2010risk and primary PCI. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22263","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T22:52:48Z","timestamp":1259189568000},"page":"187-194","source":"Crossref","is-referenced-by-count":78,"title":["Effects of mechanical left ventricular unloading by impella on left ventricular dynamics in high\u2010risk and primary percutaneous coronary intervention patients"],"prefix":"10.1002","volume":"75","author":[{"given":"Maurice","family":"Remmelink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krischan D.","family":"Sjauw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 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