{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:45:00Z","timestamp":1768455900999,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T00:00:00Z","timestamp":1264377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: To evaluate the effect of thrombus aspiration in a real\u2010world all\u2010comer patient population with STEMI undergoing primary PCI. <jats:styled-content>Background<\/jats:styled-content>: Catheter thrombus aspiration in primary PCI was beneficial in randomized clinical trials. <jats:styled-content>Methods<\/jats:styled-content>: We enrolled 313 STEMI patients presenting with TIMI Flow Grade 0 or 1 in the infarct related artery at baseline angiogram undergoing primary PCI. Patients were divided in two groups based on whether thrombus aspiration was attempted. This decision was left at operator's discretion. Procedural and long\u2010term clinical outcomes were compared between the two groups. <jats:styled-content>Results<\/jats:styled-content>: Baseline characteristics were similar between groups: 194 (62%) received thrombus aspiration and 119 underwent conventional PCI. Thrombus aspiration was associated with significantly lower post\u2010PCI TIMI Frame Count values (19 \u00b1 15 vs. 25 \u00b1 17; <jats:italic>P<\/jats:italic> = 0.002) and higher TIMI Flow Grade 3 (92% vs. 73%; <jats:italic>P<\/jats:italic> &lt; 0.001). Postprocedural myocardial perfusion assessed by myocardial blush grade (MBG) was significantly increased in the thrombus aspiration group (MBG 3: 44% vs. 21%; <jats:italic>P<\/jats:italic> &lt; 0.001). No significant difference was found between the two groups in clinical outcome at 30 days. At one year, patients treated with thrombus aspiration showed significantly higher overall survival (HR 0.41, 95% CI 0.20\u20130.81; log\u2010rank <jats:italic>P<\/jats:italic> = 0.010) and MACE\u2010free survival (HR 0.49, 95% CI 0.28\u20130.85; log\u2010rank <jats:italic>P<\/jats:italic> = 0.011). <jats:styled-content>Conclusions<\/jats:styled-content>: In real\u2010world all\u2010comer STEMI patients with occluded infarct\u2010related artery, thrombus aspiration prior to PCI improves coronary flow, myocardial perfusion, and long\u2010term clinical outcome as compared with PCI in the absence of thrombus aspiration. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22465","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T16:08:21Z","timestamp":1264435701000},"page":"70-76","source":"Crossref","is-referenced-by-count":24,"title":["Thrombus aspiration in primary percutaneous coronary intervention in high\u2010risk patients with ST\u2010elevation myocardial infarction: A real\u2010world registry"],"prefix":"10.1002","volume":"76","author":[{"given":"Fabio","family":"Mangiacapra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Trana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argyrios","family":"Ntalianis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Heyndrickx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Vanderheyden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Bartunek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"De Bruyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12113-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134791.68010.FA"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.5.570"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.3035"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07120-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.23.2302"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(04)01330-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.058"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn416"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)01041-6"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.01.011"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.057"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.9.1063"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.031"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.068"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.074716"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.044"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV4I2A40"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.09.091"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706416"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60833-8"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.017"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn421"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn389"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp348"},{"key":"e_1_2_6_27_2","first-page":"932","article-title":"Phase I findings. 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