{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T01:23:58Z","timestamp":1761960238813,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objective<\/jats:styled-content>: To assess the efficacy of the MGuard<jats:sup>TM<\/jats:sup> stent combining a polymer\u2010mesh sleeve attached to the external surface of a bare\u2010metal stent in preventing distal embolization during percutaneous coronary intervention (PCI). <jats:styled-content>Background<\/jats:styled-content>: Distal embolization of thrombus\/platelet agreggates is associated with worse immediate and long\u2010term prognosis after PCI. Treatment of saphenous vein graft (SVG) and PCI in the setting of acute coronary syndromes (ACS) is often related to this complication. Although protection and aspiration devices have been shown to reduce distal embolization, they add time and cost to PCI. <jats:styled-content>Methods<\/jats:styled-content>: A total of 30 patients were included. Inclusion criteria were de novo lesions in SVG or native vessels with angiographic evidence of instability with potential to provoke flow disturbances and\/or distal embolization. Primary endpoint included the incidence of major adverse cardiac events (MACE) (composite of cardiac death, non\u2010fatal myocardial infarction and TLR) up to 30 days of the procedure and TIMI flow right after the PCI. <jats:styled-content>Results<\/jats:styled-content>: Mean population age was 60.8 years with 36.7% of diabetes. Overall, 53.3% presented with ACS, and most lesions were located in SVG (16 of 30). The majority of lesions had complex morphology including the presence of thrombus (30%) and ulcer (33.3%). The MGuard stent was successfully deployed in all cases with no angiographic\/clinical complications including distal embolization. Final TIMI\u20103\/blush\u20103 were achieved in all cases with no MACE up to 30 days of the procedure. <jats:styled-content>Conclusions<\/jats:styled-content>: In this preliminary evaluation, the MGuard device demonstrated excellent performance in a highly complex lesion subset, including absence of angiograhpic\/procedural complications, and no adverse events up to 30\u2010day FU. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22473","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T03:01:01Z","timestamp":1275447661000},"page":"86-92","source":"Crossref","is-referenced-by-count":27,"title":["Preliminary results of the INSPIRE trial with the novel MGuard\u2122 stent system containing a protection net to prevent distal embolization"],"prefix":"10.1002","volume":"76","author":[{"given":"Felipe","family":"Maia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"J.","family":"Ribamar Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Abizaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Feres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Staico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimytri","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius","family":"Esteves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Eduardo Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21715"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(04)01330-0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2172"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.054"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.08.054"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065221.06430.ED"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02484-1"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118496.44135.A7"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi167"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV4I1A19"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.051"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02457-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2007.12.002"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.4.1193"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1160\/TH06-06-0319","article-title":"Prevention of distal embolization in patients undergoing mechanical revascularization for acute myocardial infarction. A review of current status","volume":"96","author":"De Luca G","year":"2006","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20990"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.04.058"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.057"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.068"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706416"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60833-8"},{"key":"e_1_2_7_24_2","first-page":"511","article-title":"Coronary stenting with MGuard: First\u2010in\u2010man trial","volume":"20","author":"Kaluski E","year":"2008","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22075"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.22473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.22473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:51:26Z","timestamp":1696967486000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.22473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,24]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1002\/ccd.22473"],"URL":"https:\/\/doi.org\/10.1002\/ccd.22473","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2010,6,24]]}}}