{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:02:53Z","timestamp":1770912173331,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T00:00:00Z","timestamp":1266883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: We compared the long\u2010term outcomes of drug\u2010eluting stents (DES) versus bare\u2010metal stents (BMS) for treatment of bare\u2010metal in\u2010stent restenosis (ISR). <jats:styled-content>Background<\/jats:styled-content>: There are no randomized trials or observational studies directly comparing the safety and efficacy of DES versus BMS for treatment of bare\u2010metal ISR. <jats:styled-content>Methods<\/jats:styled-content>: We examined data on all patients who underwent percutaneous coronary intervention (PCI) for ISR at Cleveland Clinic between 05\/1999 and 06\/2007. We compared the efficacy and safety of DES to BMS for treating bare\u2010metal ISR. The primary end point was a composite of death, myocardial infarction (MI), or target lesion revascularization (TLR). The secondary endpoints were individual components of the primary endpoint. <jats:styled-content>Results<\/jats:styled-content>: Of the 931 patients identified over 8 years, 706 had bare\u2010metal ISR and met our study criteria. Of the 706 patients with bare\u2010metal ISR, 362 were treated with DES and 344 with BMS. There were 230 cumulative events for a median follow\u2010up of 3.2 years. After adjusting for 27 variables, DES were associated with lower primary endpoint compared to BMS for treatment of bare\u2010metal ISR (21% vs. 45%, adjusted hazard ratio [HR] 0.63; 95% confidence interval [CI], 0.42\u20130.95; <jats:italic>P<\/jats:italic> = 0.03). The individual secondary endpoint of death (8% vs. 24%, <jats:italic>P<\/jats:italic> = 0.005) favored DES, but MI (3% vs. 8%, <jats:italic>P<\/jats:italic> = 0.31), and TLR (13% vs. 20%, <jats:italic>P<\/jats:italic> = 0.23) failed to reach statistical significance. <jats:styled-content>Conclusions<\/jats:styled-content>: In our multivariate analysis of patients with bare\u2010metal ISR, DES use was associated with significantly lower death, MI, or TLR when compared to BMS. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22509","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T16:01:18Z","timestamp":1266940878000},"page":"257-262","source":"Crossref","is-referenced-by-count":18,"title":["Drug\u2010eluting stents versus bare\u2010metal stents for treatment of bare\u2010metal in\u2010stent restenosis"],"prefix":"10.1002","volume":"76","author":[{"given":"Inder M.","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Filby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredy","family":"El Sakr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiran Z.","family":"Gorodeski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Michael","family":"Lincoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi H.","family":"Shishehbor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310802"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310801"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.707331"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22278"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.08.011"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.10.002"},{"key":"e_1_2_6_9_2","first-page":"401","article-title":"Clinical presentation of patients with in\u2010stent restenosis in the drug\u2010eluting stent era","volume":"20","author":"Lee MS","year":"2008","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199706123362402"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101253440402"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07741-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.06.087"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.8.789"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.103347"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.09.054"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-726X(200101)52:1<24::AID-CCD1007>3.0.CO;2-Y"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00852-0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.050"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032441"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.11.1264"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.11.1253"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn231"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.049"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.18.1872"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.025"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131898.18849.65"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.113998"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21694"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.11.055"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.22509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.22509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T18:04:46Z","timestamp":1697479486000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.22509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,22]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1002\/ccd.22509"],"URL":"https:\/\/doi.org\/10.1002\/ccd.22509","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,22]]}}}