{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:46:06Z","timestamp":1791913566794,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T00:00:00Z","timestamp":1272499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Background<\/jats:styled-content>: Anticoagulant therapy is required to prevent radial artery occlusion (RAO) after transradial catheterization. There is no data comparing bivalirudin to standard heparin. <jats:styled-content>Methods<\/jats:styled-content>: We studied 400 consecutive patients. In case of diagnostic angiography\u2010only (<jats:italic>n<\/jats:italic> = 200), they received an intravenous bolus of heparin (70 U kg<jats:sup>\u22121<\/jats:sup>) immediately before sheath removal whereas in case of angiography followed by <jats:italic>ad hoc<\/jats:italic> percutaneous coronary intervention (<jats:italic>n<\/jats:italic> = 200), they received bivalirudin (bolus 0.75 mg kg<jats:sup>\u22121<\/jats:sup>, followed by infusion at 1.75 mg\/kg\/h). RAO was assessed 4\u20138 weeks later using two\u2010dimensional echography\u2010doppler and reverse Allen's test with pulse oximetry. <jats:styled-content>Results<\/jats:styled-content>: At follow\u2010up, 21 of the 400 (5.3%) patients were found to have RAO with no significant difference between the two groups (3.5% bivalirudin vs. 7.0% heparin, <jats:italic>P<\/jats:italic> = 0.18). Patients with RAO had a significantly lower weight compared to patients without RAO (78 \u00b1 13 kg vs. 86 \u00b1 18 kg, <jats:italic>P<\/jats:italic> = 0.011). By multivariate analysis, a weight &lt;84 kg (OR: 2.78, 95% CI 1.08\u20138.00, <jats:italic>P<\/jats:italic> = 0.032) and a procedure duration \u226420 min (OR: 7.52, 95% CI 1.57\u201336.0, <jats:italic>P<\/jats:italic> = 0.011) remained strong independent predictors of RAO. All cases of radial occlusion were asymptomatic and without clinical sequelae. <jats:styled-content>Conclusion<\/jats:styled-content>: Delayed administration of bivalirudin or heparin for transradial catheterization provides similar efficacy in preventing RAO. Because of its low cost, a single bolus of heparin can be preferred in case of diagnostic angiography whereas bivalirudin can be contemplated in case of <jats:italic>ad hoc<\/jats:italic> percutaneous coronary intervention. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22610","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T13:56:40Z","timestamp":1272635800000},"page":"654-658","source":"Crossref","is-referenced-by-count":57,"title":["Comparison of bivalirudin versus heparin on radial artery occlusion after transradial catheterization"],"prefix":"10.1002","volume":"76","author":[{"given":"Sylvain","family":"Plante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren 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