{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:05Z","timestamp":1786977365826,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T00:00:00Z","timestamp":1297814400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content>Aim:<\/jats:styled-content>\n                    To perform a systematic review and meta\u2010analysis of studies reporting outcomes after drug\u2010eluting stent (DES) implantation in chronic total occlusions (CTOs).\n                    <jats:styled-content>Methods:<\/jats:styled-content>\n                    A review of publications and online databases in January 2010 retrieved 17 published studies that reported outcomes after DES implantation in CTOs: eight uncontrolled studies, seven nonrandomized comparative studies with bare\u2010metal stents (BMS), one post\u2010hoc analysis of a randomized trial, and one randomized trial. Data were pooled using random\u2010effects meta\u2010analysis models.\n                    <jats:styled-content>Results:<\/jats:styled-content>\n                    All published studies evaluated sirolimus\u2010 or paclitaxel\u2010eluting stents. All studies reporting comparative angiographic outcomes revealed less binary angiographic restenosis with DES implantation compared to BMS (odds ratio: 0.15, 95% CI: 0.08, 0.26). Over a mean follow\u2010up period of 18.9 \u00b1 16.5 months, the cumulative incidence of death, myocardial infarction, or stent thrombosis was similar between DES and BMS in all studies. Target lesion revascularization (odds ratio: 0.13, 95% CI: 0.06, 0.26) and target vessel revascularization (odds ratio 0.18, 95% CI: 0.11, 0.31) at 6\u201312 months were consistently lower among DES\u2010treated patients. Similar patterns of safety and efficacy event rates were also observed in studies reporting &gt;12 month outcomes.\n                    <jats:styled-content>Conclusions:<\/jats:styled-content>\n                    Compared with BMS, treatment of chronic total coronary occlusions with DES is associated with significant reductions in angiographic and clinical restenosis with similar safety. The consistency and magnitude of treatment effect across both individual trials and the pooled analysis establish DES as the preferred therapy for percutaneous revascularization of CTOs. \u00a9 2010 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ccd.22690","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T12:59:01Z","timestamp":1276520341000},"page":"315-332","source":"Crossref","is-referenced-by-count":38,"title":["Use of drug\u2010eluting stents for chronic total occlusions: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"77","author":[{"given":"Bilal","family":"Saeed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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