{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:25:55Z","timestamp":1777937155556,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T00:00:00Z","timestamp":1290124800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2010,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives:<\/jats:styled-content> To assess protocols, demographics, and hemodynamics in pediatric patients undergoing catheterization for pulmonary hypertension (PH). <jats:styled-content>Background:<\/jats:styled-content> Pediatric specific data is limited on PH. <jats:styled-content>Methods:<\/jats:styled-content> Review of the Mid\u2010Atlantic Group of Interventional Cardiology (MAGIC) collaboration PH registry dataset. <jats:styled-content>Results:<\/jats:styled-content> Between November 2003 and October 2008, seven institutions submitted data from 177 initial catheterizations in pediatric patients with suspected PH. Pulmonary arterial hypertension associated with congenital heart disease (APAH\u2010CHD) (<jats:italic>n<\/jats:italic> = 61, 34%) was more common than idiopathic PAH (IPAH) (<jats:italic>n<\/jats:italic> = 36, 20%). IPAH patients were older with higher mean pulmonary arterial pressures (mPAP) (<jats:italic>P<\/jats:italic> &lt; 0.01). Oxygen lowered mPAP in patients with IPAH (<jats:italic>P<\/jats:italic> &lt; 0.01) and associated PAH not related to congenital heart disease (APAH\u2010non CHD) (<jats:italic>P<\/jats:italic> &lt; 0.01). A synergistic effect was seen with inhaled Nitric Oxide (iNO) (<jats:italic>P<\/jats:italic> &lt; 0.01). Overall 9\/30 (29%) patients with IPAH and 8\/48 (16%) patients with APAH\u2010non CHD were reactive to vasodilator testing. Oxygen lowered pulmonary vascular resistance index (PVRI) in patients with APAH\u2010CHD (<jats:italic>P<\/jats:italic> &lt; 0.01). There was no additive effect with iNO but a subset of patients required iNO to lower PVRI below 5 WU\u00b7m<jats:sup>2<\/jats:sup>. General anesthesia (GA) lowered systemic arterial pressure (<jats:italic>P<\/jats:italic> &lt; 0.01) with no difference between GA and procedural sedation on mPAP or PVRI. Adverse events were rare (<jats:italic>n<\/jats:italic> = 7) with no procedural deaths. <jats:styled-content>Conclusions:<\/jats:styled-content> Pediatric patients with PH demonstrate a higher incidence of APAH\u2010CHD and neonatal specific disorders compared to adults. Pediatric PH patients may demonstrate baseline mPAP &lt; 40 mm Hg but &gt; 50% systemic illustrating the difficulty in applying adult criteria to children with PH. Catheterization in children with PH is relatively safe. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22693","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T16:58:05Z","timestamp":1276534685000},"page":"865-873","source":"Crossref","is-referenced-by-count":55,"title":["Assessment of pulmonary hypertension in the pediatric catheterization laboratory: Current insights from the magic registry"],"prefix":"10.1002","volume":"76","author":[{"given":"Kevin D.","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Scott","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen D.","family":"Everett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Dunbar","family":"Ivy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Donald","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.011"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.024"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192230"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2913"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.02.020"},{"key":"e_1_2_5_10_2","first-page":"346","article-title":"Severe pulmonary hypertension: Data from the Swiss Registry","volume":"131","author":"Stricker H","year":"2001","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1_suppl.78S"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80125-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0971"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0904-x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)80405-2"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.012"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2009.09.003"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2006.00128.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68615-7"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0075"},{"key":"e_1_2_5_21_2","article-title":"Prevalence and prognostic value of acute pulmonary vasodilator response in children and adults with pulmonary arterial hypertension (Abs.)","author":"Douwes JM","year":"2009","journal-title":"Eur Soc Cardiol"},{"issue":"12","key":"e_1_2_5_22_2","first-page":"I76","article-title":"Inhaled Nitric Oxide as a Preoperative Test (INOP Test I): The INOP Test Study Group","volume":"106","author":"Balzer DT","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1197"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1_suppl.14S"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207093270203"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.032"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2005.05.004"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80384-1"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.674002"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.488486"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.59.4.480"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.5.873"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90340-8"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2009.09.005"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000255732.16057.1c"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.061"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.22693","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.22693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T07:29:07Z","timestamp":1700551747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.22693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,15]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,11,15]]}},"alternative-id":["10.1002\/ccd.22693"],"URL":"https:\/\/doi.org\/10.1002\/ccd.22693","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,15]]}}}