{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:22:55Z","timestamp":1761862975811},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T00:00:00Z","timestamp":1296604800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: To compare the long\u2010term risks of coronary bifurcation lesions treated with side\u2010branch stenting using drug\u2010eluting versus bare\u2010metal stents. <jats:styled-content>Background<\/jats:styled-content>: Side\u2010branch stenting is an off\u2010label practice, but when needed, the incidence of late adverse events may differ between drug\u2010eluting and bare\u2010metal stents. <jats:styled-content>Methods<\/jats:styled-content>: We systematically searched PubMed, and the National Institutes of Health and Cochrane Registries for studies of coronary bifurcation stenting reporting clinical outcomes over at least 5 months. Data were extracted and cross checked independently by two investigators for inclusion in an observational meta\u2010analysis. Clinical outcomes included major adverse clinical events (MACE), death, myocardial infarction, target vessel revascularization (TVR), and definite stent thrombosis. We used random\u2010effects models and meta\u2010regression in 6,825 subjects from 42 studies. <jats:styled-content>Results<\/jats:styled-content>: Most (79%) of the heterogeneity in MACE between treatment groups was explained by differences in stent type, side\u2010branch stenting, and length of follow\u2010up. Compared with drug\u2010eluting stents without side\u2010branch stenting, drug\u2010eluting stents with side\u2010branch stenting had a 3% higher incidence of myocardial infarction [95% confidence interval (CI) = 0.3%, 5%, <jats:italic>P<\/jats:italic> &lt; 0.05], but no significant increase in MACE, death, TVR, or stent thrombosis. Bare\u2010metal stenting without side\u2010branch stenting had 10% (95% CI = 3%, 16%, <jats:italic>P<\/jats:italic> &lt; 0.01) higher MACE, and 10% (95% CI = 4%, 17%, <jats:italic>P<\/jats:italic> &lt; 0.01) higher TVR, whereas bare\u2010metal side\u2010branch stenting had 31% (95% CI = 23%, 39%, <jats:italic>P<\/jats:italic> &lt; 0.001) higher MACE, and 19% (95% CI = 10%, 28%, <jats:italic>P<\/jats:italic> &lt; 0.001) higher TVR. <jats:styled-content>Conclusions<\/jats:styled-content>: Side\u2010branch stenting has a much smaller impact on long\u2010term MACE with drug\u2010eluting stents compared with bare\u2010metal stents. Although this study does not support routine side\u2010branch stenting, when side\u2010branch stenting is required, drug\u2010eluting stents are associated with less adverse outcomes.\u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22750","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T05:42:32Z","timestamp":1283924552000},"page":"202-212","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010term risk of clinical events from stenting side branches of coronary bifurcation lesions with drug\u2010eluting and bare\u2010metal stents: An observational meta\u2010analysis"],"prefix":"10.1002","volume":"77","author":[{"given":"Payman","family":"Zamani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Kinlay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60314-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.17.2126"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.600155"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01482-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.065"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.06.002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.781377"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071076"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.18.1992"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067722"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.026"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.18.2001"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068304"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118474.71662.E3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn455"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.05.029"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.664920"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.808402"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.888297"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.11.030"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.03.075"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00648-8"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00591-2"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20870"},{"key":"e_1_2_6_26_2","first-page":"447","article-title":"Coronary bifurcation lesions: To stent one branch or both?","volume":"16","author":"Assali AR","year":"2004","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21194"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200702010-00002"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20951"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1157\/13087898"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.04.033"},{"key":"e_1_2_6_32_2","first-page":"739","article-title":"Coronary stenting beyond standard indications. 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