{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:45:10Z","timestamp":1791315910964,"version":"4.3.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T00:00:00Z","timestamp":1286841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objective:<\/jats:styled-content> To determine if pulsed cavitational ultrasound therapy (histotripsy) can accurately and safely generate ventricular septal defects (VSDs) through the intact chest of a neonatal animal, with the eventual goal of developing a noninvasive technique of creating intra\u2010cardiac communications in patients with congenital heart disease. <jats:styled-content>Background:<\/jats:styled-content> Histotripsy is an innovative ultrasonic technique that generates demarcated, mechanical tissue fractionation utilizing high intensity ultrasound pulses. Previous work has shown that histotripsy can create atrial septal defects in a beating heart in an open\u2010chest canine model. <jats:styled-content>Methods:<\/jats:styled-content> Nine neonatal pigs were treated with transcutaneous histotripsy targeting the ventricular septum. Ultrasound pulses of 5\u2010\u03bcsec duration at a peak negative pressure of 13 MPa and a pulse repetition frequency of 1 kHz were generated by a 1 MHz focused transducer. The procedure was guided by real\u2010time ultrasound imaging. <jats:styled-content>Results:<\/jats:styled-content> VSDs were created in all pigs with diameters ranging from 2 to 6.5 mm. Six pigs were euthanized within 2 hrs of treatment, while three were recovered and maintained for 2\u20133 days to evaluate lesion maturation and clinical side effects. There were only transient clinical effects and pathology revealed mild collateral damage around the VSD with no significant damage to other cardiac or extra\u2010cardiac structures. <jats:styled-content>Conclusions:<\/jats:styled-content> Histotripsy can accurately and safely generate VSDs through the intact chest in a neonatal animal model. These results suggest that with further advances, histotripsy can be a useful, noninvasive technique to create intracardiac communications, which currently require invasive catheter\u2010based or surgical procedures, to clinically stabilize newborn infants with complex congenital heart disease. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22787","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T18:57:34Z","timestamp":1284749854000},"page":"580-588","source":"Crossref","is-referenced-by-count":38,"title":["Therapeutic ultrasound to noninvasively create intracardiac communications in an intact animal model"],"prefix":"10.1002","volume":"77","author":[{"given":"Gabe E.","family":"Owens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan 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