{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:53:10Z","timestamp":1780095190117,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: The objective of this study was to compare the efficacy and long\u2010term clinical outcome of manual thrombus aspiration with the Export catheter (Medtronic, Minneapolis, MN) versus mechanical thrombus cutting\/aspiration with the X\u2010sizer system (eV3, White Bear Lake, MN) in primary percutaneous coronary intervention (PPCI). <jats:styled-content>Background<\/jats:styled-content>: In PPCI for acute ST\u2010segment elevation myocardial infarction (STEMI), markers of myocardial reperfusion are improved with adjunctive thrombectomy. Previous studies of different devices showed a variability in performance, suitability, and short\u2010term clinical outcome. In current literature, no direct comparison is available. <jats:styled-content>Methods<\/jats:styled-content>: We prospectively randomized 201 patients admitted for PPCI for STEMI to either the Export catheter or the X\u2010sizer prior to stent deployment. Technical success in advancing to and across the lesion, improvement of flow, reduction of thrombus, and the effect on ST\u2010segment resolution were examined. The primary endpoint of the follow\u2010up study was the combined endpoint of cardiac death, recurrent myocardial infarction (MI), or target\u2010vessel revascularization (TVR) at 3 years. <jats:styled-content>Results<\/jats:styled-content>: Although the Export catheter was more successfully deployed, other procedural parameters were similar with a trend toward better ST\u2010segment resolution (56.6% vs. 44%; <jats:italic>P<\/jats:italic> = 0.06) as compared to the X\u2010sizer system. The occurrence of the primary clinical endpoint at 3 years was 22.2% and 18.6%, respectively (HR 1.20; 95% CI 0.65\u20132.22; <jats:italic>P<\/jats:italic> = 0.35). <jats:styled-content>Conclusion<\/jats:styled-content>: Despite shorter procedural times, better lesion crossing, and fewer complications, both surrogate endpoints as well as 3\u2010year clinical follow\u2010up were similar with the use of the Export catheter as compared to the X\u2010sizer system. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.22932","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T18:44:31Z","timestamp":1294944271000},"page":"14-19","source":"Crossref","is-referenced-by-count":18,"title":["A randomized comparison of manual versus mechanical thrombus removal in primary percutaneous coronary intervention in the treatment of ST\u2010segment elevation myocardial infarction (TREAT\u2010MI)"],"prefix":"10.1002","volume":"78","author":[{"given":"Maarten 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T.","family":"Dirksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Amoroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton","family":"Slagboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GertJan","family":"Laarman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Kiemeneij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198010163031601"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.50.2.127"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911043411901"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912233412601"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.3035"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000030189.27175.4E"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.768"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.031"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.068"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.951"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)01041-6"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.08.019"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn389"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn421"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60833-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.044"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(04)01330-0"},{"key":"e_1_2_6_19_2","first-page":"445","article-title":"Free coronary perforation after X\u2010sizer\u00ae thrombectomy: Experience of two cases and review of the literature","volume":"17","author":"Lee CH","year":"2005","journal-title":"J Invasive cardiol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10701"},{"key":"e_1_2_6_21_2","first-page":"180","article-title":"Rupture and intracoronary entrapment of an angioplasty guidewire with the X\u2010Sizer thromboatherectomy catheter during rescue angioplasty","volume":"57","author":"Lopez\u2010Minguez JR","year":"2004","journal-title":"Rev Esp 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