{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:46:50Z","timestamp":1762098410288},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold> The aims of this study were to investigate the long\u2010term clinical outcomes of patients with successful versus unsuccessful revascularization with drug\u2010eluting stents (DES) for chronic total occlusion (CTO). <jats:bold>Background:<\/jats:bold> The benefits of successful revascularization of CTO remain unclear. <jats:bold>Methods:<\/jats:bold> Consecutive patients (<jats:italic>n<\/jats:italic> = 333) with \u201ctrue\u201d CTO, defined as Thrombolysis In Myocardial Infarction (TIMI) flow grade 0 on angiography and duration \u22653 months, were divided into two groups, those with successful (CTO success group, <jats:italic>n<\/jats:italic> = 251) and unsuccessful (CTO failure group, <jats:italic>n<\/jats:italic> = 82) revascularization with DES for CTO lesions. The primary endpoint was defined as major adverse cardiac events (MACE) the composite of death, Q\u2010wave myocardial infarction (MI), or target vessel revascularization (TVR). <jats:bold>Results:<\/jats:bold> The CTO success group was significantly younger, with a higher involvement of LAD, and lower incidences of renal failure, previous myocardial infarction, and previous coronary intervention than the CTO failure group. After a median follow up of 1,317 days (interquartile range, 1,059\u20131,590 days), there were no significant between\u2010group differences in rate of MACE, both after crude analysis (9.4% vs. 11.8%, log\u2010rank <jats:italic>P<\/jats:italic> = 0.16) and after adjustment (HR 1.17; 95% CI 0.47\u20132.88, <jats:italic>P<\/jats:italic> = 0.53). On multivariate analysis, major predictors of MACE were left ventricle ejection fraction (LVEF) &lt;40% (HR 3.14; 95% CI 1.39\u20137.09, <jats:italic>P<\/jats:italic> = 0.005) and multiple CTO (HR 2.38; 95% CI 1.01\u20135.71, <jats:italic>P<\/jats:italic> = 0.049). <jats:bold>Conclusions:<\/jats:bold> Long\u2010term clinical outcomes were similar in the CTO success and failure groups. Multiple CTOs and LVEF &lt;40% in CTO patients were independent predictors of MACE. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ccd.23019","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T15:08:26Z","timestamp":1301497706000},"page":"346-353","source":"Crossref","is-referenced-by-count":26,"title":["Long\u2010term clinical outcomes of successful versus unsuccessful revascularization with drug\u2010eluting stents for true chronic total 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