{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:23:07Z","timestamp":1771327387869,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:00:00Z","timestamp":1330992000000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: To investigate the predictive value of the contrast media volume to creatinine clearance (V\/CrCl) ratio for the risk of contrast\u2010induced nephropathy (CIN) (i.e., within 48\u201372 hr) and to determine a relatively safe V\/CrCl cut\u2010off value to avoid CIN in patients following percutaneous coronary intervention (PCI). <jats:styled-content>Background<\/jats:styled-content>: The V\/CrCl ratio is a pharmacokinetic risk factor for an early abnormal increase in serum creatinine (i.e., within 24 hr) after PCI. <jats:styled-content>Methods<\/jats:styled-content>: V\/CrCl ratios were obtained from 1,140 consecutive consenting patients after unselective PCI. Receiver\u2010operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V\/CrCl. The predictive value of V\/CrCl for the risk of CIN was assessed using multivariate logistic regression. <jats:styled-content>Results<\/jats:styled-content>: Fifty\u2010five (4.8%) patients out of 1,140 developed CIN. There was a significant association between higher V\/CrCl ratio values and risk of CIN in the overall population: 1.4%, 1.4%, 5.7%, and 10.9% for quartile 1 (Q1) of the V\/CrCl value (&lt;1.56, <jats:italic>n<\/jats:italic> = 283), Q2 (1.56\u20132.27, <jats:italic>n<\/jats:italic> = 289), Q3 (2.28\u20133.42, <jats:italic>n<\/jats:italic> = 282), and Q4 (&gt;3.42, <jats:italic>n<\/jats:italic> = 285) of contrast, respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). ROC curve analysis indicated that a V\/CrCl ratio of 2.62 was a fair discriminator for CIN (C\u2010statistic 0.73). After adjusting for other known predictors of CIN, V\/CrCl ratios &gt; 2.62 remained significantly associated with CIN (odds ratio: 2.20; 95% confidence interval: 1.00\u20134.81, <jats:italic>P<\/jats:italic> &lt; 0.05). <jats:styled-content>Conclusion<\/jats:styled-content>: A V\/CrCl ratio &gt; 2.62 was a significant and independent predictor of CIN after PCI in unselected patients. \u00a9 2011 Wiley Periodicals, Inc<\/jats:p>","DOI":"10.1002\/ccd.23048","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T17:29:52Z","timestamp":1318354192000},"page":"70-75","source":"Crossref","is-referenced-by-count":36,"title":["Contrast medium volume to creatinine clearance ratio: A predictor of contrast\u2010induced nephropathy in the first 72 hours following percutaneous coronary 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