{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T11:42:43Z","timestamp":1700480563817},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T00:00:00Z","timestamp":1305158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objectives<\/jats:styled-content>: The aim of our study is to evaluate the safety and efficacy of DES implantation in an unselected, \u201creal world,\u201d high\u2010risk population. <jats:styled-content>Background<\/jats:styled-content>: Several clinical trials showed that drug\u2010eluting stents (DESs) implantation is safe and effective in selected population. In spite of these encouraging results, there are some concerns about \u201creal world\u201d utilization of these stents. <jats:styled-content>Methods<\/jats:styled-content>: One thousand four hundred and fifty\u2010five off\u2010label patients have been included in our registry. Primary end\u2010points were: long\u2010term clinical incidence of major adverse cardiac and cerebrovascular events (MACCE) and thrombosis (ST). We detected the difference between uniDES vs. multiDES implantation in terms of MACCE, death, nonfatal\u2010MI, the composite of death\/nonfatal\u2010MI and target lesion revascularization (TLR) and the difference between DES type in term of MACCE. <jats:styled-content>Results<\/jats:styled-content>: At 36 months follow\u2010up we found: cardiac death occurred in 20 patients (1.6%); 33 patients (2.6%) had a nonfatal MI and 81 patients (6.3%) had a TLR. We observed one (0.1%) acute, 9 subacute (0.6%), 6 late (0.6%), and 1 (0.5%) very late definite ST. No difference were found in terms of overall MACCE, MI, death and composite of death\/nonfatal\u2010MI between uni\u2010 and multiDES implantation but multiDES group had a higher incidence of TLR. No difference between DES type in term of MACCE was detected. <jats:styled-content>Conclusions<\/jats:styled-content>: DES utilization shows their safety and efficacy in off\u2010label patients with complex clinical and angiographic profile in terms of long\u2010term incidence of MACCE. MultiDES implantation is associated with a higher risk of long\u2010term TLR. No difference between DES type was found. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.23050","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T19:22:02Z","timestamp":1305228122000},"page":"1068-1075","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term outcome after drug\u2010eluting stent implantation in unselected population: ROME and UDINE Experience (The RUDI 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