{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:03:35Z","timestamp":1789034615601,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:00:00Z","timestamp":1330992000000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Aim<\/jats:styled-content>: There are limited data on the mid\u2010term safety following the use of the guided\u2010subintimal tracking and re\u2010entry (guided\u2010STAR) technique for the treatment of chronic total occlusions (CTO) and concerns have arisen about a potential increased risk of stent thrombosis (ST). Objectives: The aim of this study was to evaluate the mid\u2010term safety in terms of cardiac death and ST after recanalization using the contrast guided\u2010STAR technique when compared to conventional anterograde CTO recanalization (CA\u2010CTO). <jats:styled-content>Methods and Results<\/jats:styled-content>: This retrospective study analyzed 355 consecutive patients with successful angiographic recanalization (residual stenosis &lt;20% and TIMI flow grade \u22652) of CTO lesion. Seventy\u2010four (20.8%) underwent guided\u2010STAR and 281 (79.2%) had CA\u2010CTO. Survival rates were estimated using the Kaplan\u2010Meier method. Compared to CA\u2010CTO patients, the rate of the following clinical, angiographic, and procedural characteristics were significantly higher in guided\u2010STAR patients: hypercholesterolemia (84 vs. 67%, <jats:italic>P<\/jats:italic> = 0.004), previous CABG (41.3 vs. 15.7%, <jats:italic>P<\/jats:italic> &lt; 0.0001), three\u2010vessel disease, (62.7 vs. 47%, <jats:italic>P<\/jats:italic> = 0.019), right coronary artery CTO (62.7 vs. 41.6%, <jats:italic>P<\/jats:italic> = 0.002), stent length (68.15 vs. 54.05 mm, <jats:italic>P<\/jats:italic> &lt; 0.0001). A drug\u2010eluting stent was implanted in the majority of cases (89.2% guided\u2010STAR vs. 93.5% CA\u2010CTO). At a median follow\u2010up of 779 days (IQR 495\u20131035), there were no significant differences in cardiac survival (97.2 vs. 97.5%, Log\u2010rank <jats:italic>P<\/jats:italic> = 0.912) and cumulative ARC ST rates (2.8 vs. 1.8%, Log\u2010rank <jats:italic>P<\/jats:italic> = 0.610) for guided\u2010STAR and CA\u2010CTO patients, respectively. The rate of restenosis was significantly higher in the guided\u2010STAR group compared to the CA\u2010CTO group (54 vs. 30%, Log\u2010rank <jats:italic>P<\/jats:italic> &lt; 0.0001). The adjusted Cox proportional\u2010hazard analysis for procedural technique showed that the only significant independent predictor of restenosis was the stent length (HR, 1.017; 95% CI, 1.008\u20131.027; <jats:italic>P<\/jats:italic> &lt; 0.0001). <jats:styled-content>Conclusion<\/jats:styled-content>: At mid\u2010term follow\u2010up, the guided\u2010STAR was not inferior to CA\u2010CTO in terms of safety. The only significant independent predictor of restenosis was the stent length. \u00a9 2011 Wiley Periodicals, Inc<\/jats:p>","DOI":"10.1002\/ccd.23058","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T17:35:10Z","timestamp":1311960910000},"page":"20-27","source":"Crossref","is-referenced-by-count":56,"title":["Coronary chronic total occlusions"],"prefix":"10.1002","volume":"79","author":[{"given":"Cosmo","family":"Godino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios 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