{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:23:50Z","timestamp":1761863030347},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T00:00:00Z","timestamp":1320192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>: The aim of this study was to compare the pharmacokinetics of the four limus\u2010eluting stents used in Japanese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background:<\/jats:title><jats:p>: There are presently no reports comparing human pharmacokinetics among drug\u2010eluting stents (DESs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>: We retrospectively analyzed data from pharmacokinetic studies of patients implanted with an 18\u2010mm DES: Cypher stent (sirolimus, <jats:italic>n<\/jats:italic> = 10), Endeavor stent (zotarolimus, <jats:italic>n<\/jats:italic> = 7), Xience V stent (everolimus, <jats:italic>n<\/jats:italic> = 6), and Nobori stent (biolimus A9, <jats:italic>n<\/jats:italic> = 10), in multicenter trials of Japan. Total drug doses of the Cypher stent, Endeavor stent, Xience V stent, and Nobori stent were 150, 180, 88, and 293 \u03bcg, respectively. Drug concentrations were measured in serial whole blood samples after implantation and the pharmacokinetics were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>: Mean peak drug levels were 0.86 ng mL<jats:sup>\u22121<\/jats:sup> for Cypher, 1.80 ng mL<jats:sup>\u22121<\/jats:sup> for Endeavor, 0.50 ng mL<jats:sup>\u22121<\/jats:sup> for Xience V, and 0.09 ng mL<jats:sup>\u22121<\/jats:sup> for Nobori. After adjustment for the loaded dose, mean peak drug levels of the Cypher and Xience V stents were similar (0.0057 ng mL<jats:sup>\u22121<\/jats:sup> \u03bcg<jats:sup>\u22121<\/jats:sup> each) while the Endeavor (0.0100 ng mL<jats:sup>\u22121<\/jats:sup> \u03bcg<jats:sup>\u22121<\/jats:sup>) was higher, and the Nobori (0.0003 ng mL<jats:sup>\u22121<\/jats:sup> \u03bcg<jats:sup>\u22121<\/jats:sup>) was lower, compared with the Cypher and Xience V stents. The other pharmacokinetic parameters of four DESs differed according to characteristics of the coated drug. The systemic exposure of biolimus A9 was much lower than that of the other DESs studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>: In Japanese patients, systemic exposure was low, regardless of the type of limus drug eluted from the stents; but specific pharmacokinetic activities were varied according to the drug characteristics, concentration, and DES design. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.23096","type":"journal-article","created":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T15:39:46Z","timestamp":1304005186000},"page":"1078-1085","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of pharmacokinetics of the limus\u2010eluting stents in Japanese patients"],"prefix":"10.1002","volume":"78","author":[{"given":"Yoritaka","family":"Otsuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Shuto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Mitsudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.826479"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.76.3.412"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033455107"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3601.093987"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200205000-00008"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000176731.59443.94"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.030"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.6.1.33"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2006.00184.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.092214"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.10.004"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA105.570093"},{"key":"e_1_2_7_14_2","first-page":"50","article-title":"The next\u2010generation endeavor resolute stent: 4\u2010month clinical and angiographic results from the Endeavor Resolute first\u2010in\u2010man trial","volume":"3","author":"Meredith IT","year":"2007","journal-title":"EuroIntervention"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.02.051"},{"key":"e_1_2_7_16_2","first-page":"426","article-title":"Randomized comparison of Nobori, biolimus A9\u2010eluting coronary stent with a Taxus(R), paclitaxel\u2010eluting coronary stent in patients with stenosis in native coronary arteries: The Nobori 1 trial","volume":"2","author":"Chevalier B","year":"2007","journal-title":"EuroIntervention"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144220"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp480"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.16.1899"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2007.11.002"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.051"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.797928"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.12.059"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155612.47040.17"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.621714"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.09.042"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.569129"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.7.1690"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.045"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.11.009"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.079"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.112513"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912700222011148"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.23096","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.23096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T10:43:33Z","timestamp":1700477013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.23096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,2]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1002\/ccd.23096"],"URL":"https:\/\/doi.org\/10.1002\/ccd.23096","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,2]]}}}