{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:28:49Z","timestamp":1791253729448,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Objective<\/jats:styled-content>: We compared use of intravenous (IV) normal saline (NS) to sodium bicarbonate (NaHCO<jats:sub>3<\/jats:sub>) with or without oral <jats:italic>N<\/jats:italic>\u2010acetylcysteine (NAC) for prevention of contrast\u2010induced acute kidney injury (CI\u2010AKI). <jats:styled-content>Background<\/jats:styled-content>: CI\u2010AKI is associated with significant adverse clinical events. Use of NAC has produced variable results. Recently, intravenous hydration with NaHCO<jats:sub>3<\/jats:sub> for CI\u2010AKI prophylaxis has been adopted as standard treatment for patients with stable chronic renal disease undergoing catheterization procedures. <jats:styled-content>Methods<\/jats:styled-content>: We prospectively enrolled 320 patients with baseline renal insufficiency scheduled to undergo catheterization. Patients were randomly assigned to receive either IV NS \u00b1 NAC (<jats:italic>n<\/jats:italic> = 161) or IV dextrose 5% in water containing 154 mEq\/l of NaHCO<jats:sub>3<\/jats:sub> \u00b1 NAC (<jats:italic>n<\/jats:italic> = 159). IV NS was administered at 1 ml\/kg body weight for 12 hr preprocedure and 12 more hr postprocedure. IV NaHCO<jats:sub>3<\/jats:sub> was administered at 3 ml\/kg body weight for 1 hr preprocedure followed by 1 ml\/kg body weight postprocedure. A 1,200 mg oral dose of NAC was given 2\u201312 hr preprocedure and 6\u201312 hr postprocedure in 50% of patients in each study arm. CI\u2010AKI was defined as an increase of &gt;0.5 mg\/dl or &gt;25% above baseline creatinine. <jats:styled-content>Results<\/jats:styled-content>: Overall incidence of CI\u2010AKI was 10.3%. There was no significant difference in incidence among the two groups (NS \u00b1 NAC 11.8% vs. NaHCO<jats:sub>3<\/jats:sub> \u00b1 NAC 8.8%, <jats:italic>p<\/jats:italic> = ns). Incidence of CI\u2010AKI increased with increasing age (<jats:italic>p<\/jats:italic> = 0.001), contrast agent use &gt;3 ml\/kg body weight (<jats:italic>p<\/jats:italic> = 0.038) and diuretic use (<jats:italic>p<\/jats:italic> = 0.005). <jats:styled-content>Conclusion<\/jats:styled-content>: Incidence of CI\u2010AKI was no different in the NaHCO<jats:sub>3<\/jats:sub> group compared to NS group, and NAC did not reduce CI\u2010AKI in the two study arms. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.23148","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T19:29:18Z","timestamp":1304450958000},"page":"929-937","source":"Crossref","is-referenced-by-count":28,"title":["Prevention of contrast\u2010induced acute kidney injury in patients with stable chronic renal disease undergoing elective percutaneous coronary and peripheral interventions: Randomized comparison of two preventive strategies"],"prefix":"10.1002","volume":"79","author":[{"given":"Abdul Moiz","family":"Hafiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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