{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:44:42Z","timestamp":1759481082510},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content>Background<\/jats:styled-content>: There is few information on the long\u2010term efficacy and safety of sirolimus\u2010eluting stents (SES) and paclitaxel\u2010eluting stents (PES) compared to bare metal stents (BMS) in all\u2010comer percutaneous coronary intervention (PCI)\u2014patients complicated by renal insufficiency (RI). <jats:styled-content>Objective<\/jats:styled-content>: Our aim was to assess the 6\u2010year clinical outcome of PCI\u2010patients with RI treated exclusively with BMS, SES, or PES in our academic hospital. <jats:bold>Methods:<\/jats:bold> A total of 1382 patients, included in three cohorts of consecutive PCI\u2010patients (BMS = 392; SES = 498; PES = 492), were categorized by creatinine clearance calculated by the Cockroft\u2013Gault formula (normal kidney function \u2265 90; mild RI = 60\u201389; moderate RI &lt; 60) and systematically followed for the occurrence of major adverse cardiac events (MACE). <jats:styled-content>Results<\/jats:styled-content>: Mortality rates were significantly higher for patients with moderate RI compared to mild RI and normal kidney function at 6 years (Kaplan\u2013Meier estimate: moderate RI (34%) vs. mild RI (12%), <jats:italic>P<\/jats:italic> &lt; 0.001; moderate RI (34%) vs. normal kidney function (8%), <jats:italic>P<\/jats:italic> &lt; 0.001). After multivariate Cox\u2010regression analysis, SES and PES decreased the occurrence of target\u2010vessel revascularization (TVR) and MACE at 6 years in patients with a normal creatinine clearance compared to BMS [adjusted hazard ratio (aHR) = 0.48, 95% CI: 0.28\u20130.84; aHR = 0.75, 95% CI: 0.57\u20130.97, respectively] with no significant effect on mortality. Safety\u2010 and efficacy end points were comparable for the three stent types in patients with mild\u2010 and moderate renal function. <jats:styled-content>Conclusion<\/jats:styled-content>: Patients with a normal creatinine clearance had significant improvement in TVR and MACE rates after SES\u2010 or PES implantation compared to BMS at 6 years. However, there was no superiority of both drug\u2010eluting stents over BMS in safety and efficacy end points for patients with impaired renal function. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.23199","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T15:17:46Z","timestamp":1309965466000},"page":"18-26","source":"Crossref","is-referenced-by-count":13,"title":["Impact of renal insufficiency on safety and efficacy of drug\u2010eluting stents compared to bare\u2010metal stents at 6 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Thoraxcenter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01745-X"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.24.2966"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.004"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.07.011"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.08.089"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.01.032"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.074"},{"key":"e_1_2_5_9_2","first-page":"330","article-title":"Two\u2010year clinical follow\u2010up of the unrestricted use of the paclitaxel\u2010eluting stents compared to the 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